TGFβ，激活素 (Activins)、抑制素、Nodal、BMP 等配体在细胞表面结合跨膜受体 I 型和 II 型的复合物，通过组成型活性的 II 型受体激酶诱导 I 型受体中 GS 域 (富含甘氨酸和丝氨酸残基) 的磷 …

2019年5月3日 · The present results show that neurons and microglia both use ALK4/5 (a type of TGF-β receptor) signaling in order to maintain mutual exchanges in an adult brain following an …

使 Smad2 和 Smad3 磷酸化的主要是TGF-β亚家族（ALK4，ALK5和ALK7）的I型受体（PS：基于ALK5的抑制剂开发较多），而Smad3对诱导HSCs活化和促纤维化基因转录至关重要。 …

2004年4月15日 · Together, these results suggest not only that ALK4 interacts with multiple TGF betas to generate embryonic pattern, but also that ALK4 ligands differentially utilize the ALK4 …

Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor …

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the transcription …

2013年1月16日 · Inhibition of signaling through the receptors ALK4, ALK5 and ALK7, and ALK5 alone, demonstrated that TGFβ signaling is required for testis cord formation during the critical …

SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 …

2008年12月30日 · TGF-β signals in most cells via TGF-β type II receptor (TβRII) and ALK5, activins via activin receptor type IIA (ActRIIA) and IIB and ALK4, and BMPs via BMP type II …

4-(4-(Benzo(d)(1,3)dioxol-5-yl)-5-(pyridin-2-yl)- 1H-imidazol- 2- yl) benzamide, also known as SB-431542, is a selective and potent inhibitor of the type I receptors of ALK4, ALK5 and ALK7 in …