HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]

Our major emphasis is on pretransplant alloantibody assessment in kidney transplant candidates, but the basic principles apply posttransplantation and to other solid organ transplants - particularly heart, lung, and pancreas.

HLA研究中，模拟免疫反应激活的过程，就要经过 蛋白酶体对抗原（蛋白）的剪切预测 、肽段转运、 肽段和MHC-I结合亲和力预测 以及 T细胞识别预测 等几个重要步骤。 一般可以采用滑动窗口（sliding windows）的方法把可能的肽段都提取出来，MHC结合亲和力预测由软件实现（但效果各有说法，最好多重比较筛选， 软件对比），更严谨的可以用抗原实验来验证（制造目标肽段，做实验查看与MHC的结合情况）。 HLA配型也叫移植配型，HLA基因座位点具有高度多态性，完 …

Antibodies that detect HLA-ABC can be used in several scientific applications, including Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Western Blot and Immunoprecipitation. These antibodies target HLA-ABC in Human, Non-human primate, Bovine, Mouse and …

Donor-specific anti-HLA antibodies (DSA) play a significant role in causing chronic antibody-mediated allograft rejection. Exposure to mismatched HLA antigens via transfusion, pregnancy, or transplanted tissue has been described in the literature …

2023年4月24日 · Human leukocyte antigens (HLA) are genes in major histocompatibility complexes (MHC) that help code for proteins that differentiate between self and non-self. They play a significant role in disease and immune defense.

2016年10月1日 · Anti-HLA antibody identification and HLA typing allow the accurate organ allocation and the graft outcome monitoring in the pre and post-transplantation time. Epigenetic tags revealed by several DNA-based methods including real time-PCR and NGS might represent promising biomarkers for graft outcome monitoring.

Non-HLA Antibodies reactive with donor endothelial cell antigens have been implicated in rejection and graft loss. The MICA Single Antigen Antibody Screen detects IgG antibodies against the most common MICA alleles and allows high throughput antibody screening and identification using Luminex technology.

This test checks your blood for antibodies against a cell marker called a human leukocyte antigen (HLA). The test is done if you need an organ transplant, to help find a donor organ that will work in your body. Different forms of the HLA antibody are involved in autoimmune diseases.

2024年12月1日 · Donor-specific anti-HLA antibodies (DSA) are an important cause of engraftment failure and may negatively impact survival outcomes of patients receiving allogeneic hematopoietic stem cell transplantation (HSCT) using an HLA-mismatched allograft.