Antibodies to U1 ribonucleoprotein particle (U1-RNP) are central to the diagnosis of mixed connective tissue disease and are also associated with other antinuclear antibody (ANA)-associated connective tissue diseases (CTDs) such as systemic lupus erythematosus, systemic sclerosis, undifferentiated CTD, and CTD overlap syndromes.(1-5 ...

2024年9月14日 · What Are Anti-RNP Antibodies? Anti-RNP antibodies are a type of autoantibody that specifically target a complex of proteins and RNA called the U1 small nuclear ribonucleoprotein (U1 snRNP). This complex is involved in critical cellular processes, like splicing RNA, which is a necessary step in gene expression.

2024年7月20日 · Detailed information on anti-RNP antibodies, used in diagnosing mixed connective tissue disease and systemic lupus erythematosus (SLE).

抗rnp抗体，是抗u1-rnp或抗u1-snrnp的简称，全中文名是抗u1小核糖核蛋白抗体，其抗原是u1小分子细胞核核糖核蛋白粒子，属于抗ena（可提取核抗原抗体）中的一种。

现在认为抗 Sm 抗体和抗 U1RNP 抗体对应的自身抗原共存于同一个独特的细胞结构中，即 核内小分子核糖核蛋白颗粒 (small nuclear ribonucleoprotein particle, snRNP)。 Sm 抗原是一类非组蛋白的核蛋白，是 SLE 中首个报道的核蛋白自身抗原。 Sm 蛋白为一系列的蛋白，命名为 SmB、SmD1、SmD2、SmD3、SmE、SmF 及 SmG。 抗 Sm 抗体可结合这些蛋白中的 1 种或多种。 Sm 蛋白构成一个七聚体环，该环与富含尿苷的细胞核小 RNA (即 U1、U2、U4 及 U5) 形成复 …

2021年5月7日 · Anti-RNP antibody levels are elevated in 100% of patients with MCTD and 38%-44% of patients with SLE. Anti-RNP antibody testing is usually ordered after a positive antinuclear antibody (ANA)...

Anti-RNP autoantibodies occur either in Mixed Connective Tissue Disease (MCTD) (with a frequently favorable prognosis), or in systemic lupus (SLE) cases with aggressive major organ disease. It is uncertain how to assess for the risk of severe ...

Anti-Sm antibodies are directed against 7 proteins (B/B', D1, D2, D3, E, F, G) that constitute the common core of U1, U2, U4 and U5 small nuclear ribonucleoprotein (snRNP) particles; B/B', D1 and D3 are more frequently targeted. Anti-RNP antibodies react with proteins (70 Kd, A, C) that are associated with U1 RNA and form U1snRNP.

Antibodies to U1 ribonucleoprotein particle (U1-RNP) are central to the diagnosis of mixed connective tissue disease and are also associated with other antinuclear antibody (ANA)-associated connective tissue diseases (CTDs) such as systemic lupus erythematosus, systemic sclerosis, undifferentiated CTD, and CTD overlap syndromes.(1-5 ...

Anti-nRNP is a type of antibody. [1] [2] They are autoantibodies against some ribonucleoproteins. [3] Anti-nRNP antibodies can be elevated in mixed connective tissue disease. [4]