Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene. [5] [6] [7] ATGL catalyses the first reaction of lipolysis, [8] where triacylglycerols are hydrolysed to …

The dissociation of CGI-58 from Plin1 enables its interaction with ATGL, which activates ATGL’s TG hydrolyzing activity. In both, basal and stimulated state of lipolysis, ATGL can be inhibited by the protein G0/G1 switch gene 2 (G0S2), acyl-CoA and synthetic inhibitor Atglistatin (which is effective in murine ATGL only).

Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy production. There is growing evidence that the products and intermediates from lipolytic breakdown during the …

2024年8月14日 · Our study focused on hepatocytes, but a previous proteomic study using adipocytes identified ATGL as a potentially S-acylated protein, although the sites and, more importantly, the role of the ...

2024年3月21日 · Here, the authors use deep mutational scanning to define the determinants of protein interaction between ATGL and its regulatory partners, gaining insights into lipolysis mechanisms in cells.

The G0/G1 switch gene-2 (G0S2) encodes a protein discovered as a selective controller of ATGL, lowering its action in both cells and mice. G0S2 is primarily expressed in adipose tissue and mature adipocytes and interacts with ATGL to specifically prevent its TAG hydrolase activity.

Recently, it has been shown that ATGL is profoundly inhibited by a small protein called hypoxia-inducible LD-associated protein (HILPDA, also known as hypoxia inducible gene 2, HIG2) which directly binds to the patatin domain of ATGL [47,48].

2024年2月27日 · Nature Chemical Biology - Adipose triglyceride lipase (ATGL), an enzyme in fatty acid metabolism, was identified as a negative regulator of the noncanonical inflammasome. ATGL binds to...

2020年9月1日 · (A) Protein expression levels of ATGL, HSL, and MGL in shControl/shATGL cancer cell lines were analyzed by western blot analysis. GAPDH was used as housekeeping protein. Equal protein loading was also verified by Coomassie blue staining of the membrane.

2023年2月1日 · The N-end rule-resistant ATGL(F2A) mutant, in which the N-terminal phenylalanine (F) of ATGL is substituted by alanine (A), has increased protein stability and enhanced lipolysis activity. ATGLF2A/F2A knock-in mice are protected against high-fat diet (HFD)-induced obesity, hepatic steatosis, and insulin resistance.