The purpose of the present article is to provide an update on some of the recently described forms of reciprocal regulation between Ca (2+) and cAMP signaling circuits, with emphasis on interactions that take place in localized domains of the cell.

2010年11月21日 · Here, we show that protein kinase A (PKA), Ca 2+ and cyclic AMP (cAMP) oscillate in sync in insulin-secreting MIN6 beta cells, forming a highly integrated oscillatory circuit.

2022年9月1日 · Ca 2+ Signaling can be modulated both acutely and chronically by the action of the cAMP/PKA signaling system. Regulation often occurs in restricted domains because of the action of scaffolding partners. The ubiquitous secondary messengers, Ca 2+ and cAMP, play a vital role in shaping a diverse array of physiological processes.

One well studied target of both calcium and cAMP signaling is the transcription factor cAMP-responsive element-binding protein (CREB). Multiple signaling pathways have been shown to contribute to the regulation of CREB-dependent transcription, including both protein kinase A (PKA)- and mitogen-activated protein (MAP) kinase/extracellular signal ...

Calcium (Ca 2+) and the cAMP-dependent protein kinase (PKA) are pleiotropic cellular regulators and both exert powerful, diverse effects on cytoskeletal dynamics, cell adhesion and cell migration.

The suggested mechanism is based on the regulation of local Ca2+ release by cyclic AMP-dependent protein kinase (PKA) and relies upon two experimental observations: first, some G-protein coupled signaling pathways activate PLC and regulate adenylate cyclase at the same time, leading to IP3 production and altering PKA activity via changes in ...

2017年11月9日 · Here we identify the functionally relevant site for PKA phosphorylation on the human cardiac L-type Ca 2+ channel pore forming α1 subunit using a novel approach. We used a cell free system where...

2019年11月19日 · In this study, we present a well-mixed model for the dynamics of calcium-induced cAMP/PKA dynamics in dendritic spines. The model is constrained using experimental observations in the literature. Further, we measured the calcium oscillation frequency in dendritic spines of cultured hippocampal CA1 neurons and used these dynamics as model inputs.

Feed-forward basal Ca (2+)-cAMP/PKA signaling both consumes ATP to drive spontaneous APs in SANC and is tightly linked to mitochondrial ATP production. Interfering with Ca (2+)-cAMP/PKA signaling not only slows the firing rate and reduces ATP consumption, but also appears to reduce ATP production so t …

The data demonstrate that 5-HT 4 receptors are positively coupled to adenylyl cyclases and cAMP-dependent protein kinases (PKA). The activation of the cAMP-PKA pathway is associated with calcium influx through T-type calcium channels. Both the adenylyl cyclase/PKA pathway and the calcium influx are involved in 5-HT-induced cortisol secretion.