Cyclic-di-GMP-Binding CRP-Like Protein: a Spectacular New Role …
It describes a CRP-like transcription factor whose affinity to DNA is regulated by c-di-GMP (Fig. 1). The CRP family proteins are expected to bind cAMP. The notion that Clp, which shares …
Structural and functional diversity of bacterial cyclic nucleotide ...
2023年5月1日 · Here, we summarize the current knowledge on structural and physiological aspects of E. coli CAP compared with other cAMP- and cGMP-activated transcription factors, …
The global regulation of c-di-GMP and cAMP in bacteria
2024年3月11日 · In contrast, due to the limited quantity, the cAMP metabolic enzymes and its major effector are regulated at different levels by diverse signals. cAMP performs its global …
cAMP Activation of the cAMP Receptor Protein, a Model Bacterial ...
2023年3月9日 · In wild-type CRP, the protein equilibrium of apo-CRP is shifted toward the alternative inactive population (apo-CRP inactive’), and cGMP binds and stabilizes the …
Two-State Allosteric Modeling Suggests Protein Equilibrium as an ...
2008年7月1日 · Activation of the cAMP receptor protein (CRP) from Escherichia coli is highly specific to its allosteric ligand, cAMP. Ligands such as adenosine and cGMP, which are …
Characterization of the binding of cAMP and cGMP to the CRP ... - PubMed
1990年9月11日 · Wild type cAMP receptor protein (CRP) activates in vitro lac transcription only in the presence of cAMP. In contrast the mutant CRP*598 (Arg-142 to His, Ala-144 to Thr) can …
CRP 蛋白对细菌环核苷酸感知的结构和功能多样性。,microLife - X …
2023年5月1日 · 在 crp 二聚体中，两个环核苷酸分子中的每一个都与两个蛋白质亚基接触并实现有利于 dna 结合的构象变化。 在这里，我们总结了大肠杆菌 CAP 与其他 cAMP 和 cGMP 激活 …
Effect of cAMP Binding Site Mutations on the Interaction of cAMP ...
1996年8月30日 · Although cAMP binding to wild type cAMP receptor protein (CRP) induces specific DNA binding and activates transcription, cyclic nucleoside monophosphate (cNMP) …
Stoichiometry and Structural Effect of the Cyclic Nucleotide …
2002年3月29日 · In this work, we performed a nuclear magnetic resonance study on CRP to investigate the stoichiometry of cyclic nucleotide binding to CRP. A series of 1 H- 15 N …
Thermodynamics of cyclic nucleotide binding to the cAMP …
1995年9月15日 · The thermodynamics of the binding of cyclic adenosine monophosphate (cAMP) and its non-functional analog, cyclic guanosine monophosphate (cGMP), to cyclic AMP …