鸟苷酸环化酶 （guanylate cyclase, GC）可将 三磷酸鸟苷 （guanosine triphosphate, GTP）催化为cGMP。 其中，与 膜受体 结合的鸟苷酸环化酶和可以在膜受体与肽类激素（如 心房钠尿肽 ）结合后被激活。

Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its most likely mechanism of action is activation of intracellular protein kinases in response to the binding of membrane -impermeable peptide hormones to the external cell surface. [ 1 ]

Define receptor guanylyl cyclases and describe their role as transmembrane enzymes that convert GTP to cyclic GMP (cGMP) upon ligand binding. Explain how these receptors integrate extracellular signals to initiate intracellular second messenger cascades.

2023年7月30日 · Guanylyl cyclase (also known as guanylate cyclase) is an enzyme that catalyzes the synthesis of cyclic guanosine 3′,5′-monophosphate (cGMP) from guanosine 5' triphosphate (GTP). Guanylyl cyclase exists in both a membrane-bound and soluble form in the cell.

1999年5月5日 · Soluble guanylate 1 cyclase (sGC) is the only conclusively proven receptor for nitric oxide (⋅ NO), a signaling agent produced by the enzyme nitric oxide synthase (NOS) from the amino acid l -arginine. As shown in Fig. 1, sGC catalyzes the conversion of guanosine 5′-triphosphate (GTP) to cyclic guanosine 3′,5′-monophosphate (cGMP).

Cyclic guanosine 3',5'-monophosphate (cGMP) is an intracellular signalling molecule involved in many sensory and developmental processes. Synthesis of cGMP from GTP is catalysed by guanylate cyclase (GC) in a reaction analogous to cAMP formation by adenylate cyclase (AC).

2024年4月1日 · The cGMP pathway, short for cyclic guanosine monophosphate pathway, is a cellular signaling mechanism where cGMP, synthesized from GTP (guanosine triphosphate), acts as a secondary messenger. It plays a critical role in regulating various physiological processes, such as vasodilation in vascular smooth muscles, phototransduction in the retina ...

2019年12月20日 · Guanylate cyclases (GCs) convert guanosine 5′‐triphosphate (GTP) into one of the most important intracellular messengers, cyclic guanosine 3′,5′‐monophosphate (cGMP). cGMP is central to many transduction pathways where it propagates signals in processes that include neurotransmission, blood pressure regulation, bone growth, lipolysis ...

Cyclic guanosine monophosphate (cGMP), generated via the guanylate cyclase (GC)-catalyzed conversion from GTP, is unequivocally recognized as crucial second messenger, intimately involved in the regulation of a broad range of physiological processes such as long term potentiation, blood pressure reg …

Stimulation of guanylyl cyclases and the resultant accumulation of cGMP regulates complex signaling cascades through immediate downstream effectors, including cGMP-dependent protein kinases, cGMP-regulated phosphodiesterases, and cyclic nucleotide-gated ion channels.