cGMP-specific phosphodiesterase type 5 - Wikipedia
The phosphodiesterase (PDE) isozymes, found in several tissues including the rod and cone photoreceptor cells of the retina, belong to a large family of cyclic nucleotide PDEs that …
磷酸二酯酶(PDEs) - 知乎 - 知乎专栏
磷酸二酯酶(PDEs) 是一系列水解cAMP 及 cGMP 的水解酶，是调节 cAMP 和 cGMP 水平的重要环节，针对 PDEs 尤其是 PDE3 和 PDE5 的干预对于心力衰竭治疗有着重要意义 环磷酸腺 …
磷酸二酯酶 - 百度百科
PDE9A是一种高度亲和性的cGMP专一的PDE，可被Zaprinast轻度抑制。PDE9缺乏与PDE2、5、6相似的cGMP结合的 立体异构 区域。PDEgA的mRNA 在肾脏高度表达 Ⅲ 。PDE10A 水 …
Phosphodiesterase 5 (PDE5): Structure-function regulation and ...
2021年2月1日 · Phosphodiesterase 5 (PDE5) is one of the most well-studied phosphodiesterases (PDEs) that specifically targets cGMP typically generated by nitric oxide (NO)-mediated …
cAMP、cGMP 信号转导通路 - 丁香通研选
2012年10月25日 · cgmp 可通过激活pde-2或抑制pde-3来调节camp 的浓度及camp /pka信号通路。
Role of phosphodiesterases in the pathophysiology of …
2021年1月7日 · Cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) are second messengers that regulate a variety of signaling pathways via direct …
cAMP and cGMP Signaling Cross-Talk | Circulation Research
2007年6月8日 · Cardiac myocytes express several cGMP-regulated cAMP-hydrolyzing PDEs that differ with respect to subcellular localization, affinity, and specificity for cAMP and cGMP. As a …
The cGMP system: components and function - PubMed
2020年3月26日 · Signal transduction by cGMP is controlled by the generating enzymes GCs, the degrading enzymes PDEs and the cGMP-regulated enzymes cyclic nucleotide-gated ion …
The perspective of cAMP/cGMP signaling and cyclic nucleotide ...
2024年3月1日 · Cyclic nucleotide phosphodiesterases (PDEs) are important in modulating cyclic nucleotide signaling through hydrolyzing cAMP and/or cGMP. The PDE superfamily comprises …
Phosphodiesterases - MilliporeSigma
PDE3, whose V max cAMP > V max cGMP and K m cGMP < K m cAMP, is generally considered as a cGMP-inhibited cAMP hydrolyzing PDE. PDEs contain a conserved, catalytic domain of …