cGMP-PKG (cyclic guanosine monophosphate-protein kinase G)信号通路是细胞内的一种重要信号转导途径。 它通过cGMP作为第二信使，调节PKG的活性，从而影响靶蛋白，参与多种生理和病理过程。

cGMP-dependent protein kinase or protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP. It phosphorylates a number of biologically important targets and is implicated in the regulation of smooth muscle relaxation, platelet function, sperm metabolism, cell division , and nucleic acid synthesis.

The elevated intracellular cGMP level exerts its physiological action through two forms of cGMP-dependent protein kinase (PKG), cGMP-regulated phosphodiesterases (PDE2, PDE3) and cGMP-gated cation channels, among which PKGs might be the primary mediator.

The elevated intracellular cGMP level exerts its physiological action through two forms of cGMP-dependent protein kinase (PKG), cGMP-regulated phosphodiesterases (PDE2, PDE3) and cGMP-gated cation channels, among which PKGs might be the primary mediator.

2020年3月1日 · The cGMP-PKG-Ca 2+ pathway plays a crucial role in modulating cardiac homeostasis. We hypothesized that the genes associated with the cGMP-PKG-Ca 2+ pathway are altered in cardiomyopathy. To address this, we employed RNA-Seq to examine the global changes in gene expression and alternative splicing (AS) in ChD (vs. control) hearts of mice.

PKG, a universal eukaryotic Ser/Thr kinase, is the most important downstream target of cGMP. What Is the cGMP-PKG Signaling Pathway? In the cGMP-PKG signaling pathway, PKG is activated by the second messenger cGMP and then transmits extracellular signals into the cell.

The elevated intracellular cGMP level exerts its physiological action through two forms of cGMP-dependent protein kinase (PKG), cGMP-regulated phosphodiesterases (PDE2, PDE3) and cGMP-gated cation channels, among which PKGs might be the primary mediator.

2014年5月12日 · We demonstrated that cGMP/protein kinase G (PKG) signaling mediates early memory consolidation as well as early-phase LTP, whereas cAMP/protein kinase A (PKA) signaling mediates late...

The elevated intracellular cGMP level exerts its physiological action through two forms of cGMP-dependent protein kinase (PKG), cGMP-regulated phosphodiesterases (PDE2, PDE3) and cGMP-gated cation channels, among which PKGs might be the primary mediator.

cgmp对血小板功能的调节起到非常重要的作用，且主要通过enos-no-cgmp-pkg通路进 行调节。 本综述主要阐明cGMP在血小板聚集中的作用和机制。