Catechol-O-methyltransferase - Wikipedia
Catechol-O-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine). The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM).
Catechol-O-Methyltransferase - an overview - ScienceDirect
Found in both peripheral tissues and the brain, catechol-O-methyltransferase (COMT) is important in the metabolism of catechol neurotransmitters including dopamine, especially in the prefrontal cortex; COMT also plays a major role in biotransformation of estrogens.
COMT gene - MedlinePlus
The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. Two versions of this enzyme are made from the gene. The longer form, called membrane-bound catechol-O-methyltransferase (MB-COMT), is …
Catechol-O-methyltransferase: characteristics, polymorphisms …
O -Methylation by catechol- O -methyltransferase (COMT) blocks their estrogenicity and prevents their oxidation to quinones. A single gene encodes both membrane bound (MB) and soluble (S) forms of COMT. The COMT gene contains 34 single nucleotide polymorphisms (SNPs).
Catechol-O-Methyltransferase (COMT): An Update on Its Role in …
Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols.
Catechol-O-methyltransferase (COMT) - ScienceDirect
2024年1月1日 · Catechol- O -methyltransferase (COMT) is a magnesium-dependent enzyme responsible for the catalytic O -methylation reaction of endogenous catecholamines and neurotransmitters. It is also involved in the metabolic process of various hormones and drugs incorporating catecholic structures.
Catechol-O-Methyl Transferase - an overview - ScienceDirect
Catechol-O-methyl transferase (COMT) is an Mg ++-dependent enzyme widely expressed in mammalian tissues. The enzyme catalyses the transfer of a methyl group from S-adenosyl-L-methionine to catechol-containing substrates.
Catechol- O -Methyltransferase - Springer
2022年1月1日 · Catechol-O-methyltransferase (COMT) is a widespread enzyme that catalyzes the transfer of the methyl group of S-adenosyl-l-methionine (AdoMet) to one of the phenolic group of the catechol substrate (Fig. 1).
Catechol‐O‐methyltransferase and Its Inhibitors in Parkinson's …
The purpose of this article is to review the current knowledge on the enzyme catechol‐ O ‐methyltransferase (COMT) and the role of COMT inhibitors in PD as a new therapeutic approach to PD involving conversion of levodopa to dopamine at the target region in the brain and facilitation of the continuous action of this amine at the receptor sites.
Structure-based drug design of catechol-O-methyltransferase …
Catechol O-methyltransferase (COMT, EC 2.1.1.6) catalyzes the methylation reaction (generally classified as phase II metabolism) whereby a methyl group from the cofactor S-adenosyl-L-methionine (SAM) is transferred to one of the catecholic hydroxyls . COMT exists in two forms.