Molecular mechanism of IgE-mediated FcεRI activation | Nature
2024年10月23日 · Monomeric immunoglobulin E (IgE) binding to FcεRI regulates mast cell survival, differentiation and maturation 6, 7, 8. However, the underlying molecular mechanism …
IgE Antibodies: From Structure to Function and Clinical Translation
Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic reactions, and their powerful effector functions activated through binding to Fc receptors FcεRI and …
生命科学学院肖俊宇团队阐明IgE高亲和力受体FcεRI复合物的组装 …
2024年9月3日 · IgE是最晚被发现的免疫球蛋白亚型，在抗毒素、抗寄生虫感染方面发挥着重要作用。 同时，IgE 也对包括花粉在内的其他外界物质和自身分子产生反应，导致过敏性疾病的出 …
Structural basis for selective inhibition of immunoglobulin E
2018年8月1日 · 8D6 is a monoclonal anti-IgE antibody that, like omalizumab and MEDI4212, inhibits the interaction between IgE and FcεRI 33, thus preventing mast cell degranulation. …
Regulation and dysregulation of immunoglobulin E: a molecular …
Altered levels of Immunoglobulin E (IgE) represent a dysregulation of IgE synthesis and may be seen in a variety of immunological disorders. The object of this review is to summarize the …
Revealed at last: Structure of the antibody-receptor complex
2024年12月10日 · Immunoglobulin E (IgE) binds with high affinity to its receptor, FcεRI, on mast cells and basophils, and cross-linking of allergen-specific IgE by minute amounts of multivalent …
Acute kidney injury induced by allergic conditions-associated renal ...
Immunological examination showed increased IgE level (3080IU/mL; normal range, 0 to 165IU/mL). The symptoms got worse gradually and the serum Cr had increased to 6.72mg/dL …
过敏检查时总IgE代表什么？ - 知乎
IgE就像是变应原（引起过敏反应的物质）在第一次进入身体后埋下的开关，就像我们的灯泡有个开关，火线和零线一接通灯就亮一样。 这些开关直接按在人体的肥大细胞和嗜碱性细胞表面。
We report the structure of an anti-IgE antibody Fab (8D6) bound to IgE-Fc through a mixed protein-carbohydrate epitope, revealing further flexibility and a novel extended conformation …
Allergen-specific IgE to following allergens: g6 Phleum pratense; d1 Dermatophagoides pteronyssinus and m6 Alternaria alternata were measured in ImmunoCAP SystemTM (Pha …