2024年12月24日 · CD274 (CD274 Molecule) is a Protein Coding gene. Diseases associated with CD274 include Hematologic Cancer and Leukemia, Acute Lymphoblastic. Among its related …

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene.

2025年2月9日 · This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells.

This gene has 5 transcripts (splice variants), 1 paralogue and is associated with 45 phenotypes.

Structural variations of the CD274/PD-L1 gene are emerging as a reasonable and relevant mechanism that can govern the increase of PD-L1 expression. Many fascinating scientific advances have been recently reported in this field. Alternatively, the epigenetic deregulation of PD-L1 is currently emerging in some tumors.

CD274程序性死亡蛋白配体1（PD-L1，CD274，B7-H1）已被确定为免疫抑制受体编程性死亡-1（PD1/ PDCD1），并已证明在调节免疫应答和外周耐受中发挥作用。 在诱导和维持对自身免疫耐受中发挥关键作用。

2024年11月5日 · This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells.

2019年2月5日 · Antibodies targeting CD274 or PDCD1 have been revealed to be effective in several malignancies. In colorectal cancer, the response to CD274/PDCD1 blockage is associated with microsatellite...

2018年12月17日 · Keywords: CD274/PD-L1; epigenetic modulation; genomic aberrations; polymorphisms. The programmed death 1 receptor (PD-1) and its ligand (PD-L1) are key molecules of immune checkpoint mechanisms in cancer and actually represent one of the main targets of immunotherapy.

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V …