CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). [1] It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.

2024年12月24日 · CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are Immune response NFAT in immune response and TCR Signaling (Qiagen).

CD3是一种多聚体蛋白复合物，又称为T3复合物，由四个不同的多肽链组成；epsilon (ε)、gamma (γ)、delta (δ)和zeta (ζ)，它们组装并作为三对二聚体（εγ、εδ、ζζ）发挥作用。

cd3蛋白是免疫系统中关键的分子之一，参与激活细胞毒性t细胞(cd8+初始t细胞)和t辅助细胞(cd4+初始t细胞)，负责监测和抵御体内的感染和异常细胞。 CD3的定义和结构：CD3由四条不同的链组成：包括CD3δ、CD3ε、CD3…

2025年3月8日 · The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

2017年4月3日 · In this study we have succeeded in establishing a novel mouse strain in which all the three components of the Cd3 complex — Cd3ε, Cd3δ, and Cd3γ — are replaced by their human counterparts, CD3E,...

The CD3 eta subunit of the T-cell receptor is thought to subserve an important role in signal transduction and possibly T-cell development. Herein we characterize the organization of the mouse CD3 eta gene and show that it is part of one gene …

2018年1月1日 · CD3 is a complex of three type 1 transmembrane (TM) proteins expressed in T cells and most likely also in some neurons: CD3γ, CD3δ, and CD3ε. CD3ζ (CD247) is described in a separate chapter due to significant differences compared to CD3γ, CD3δ, and CD3ε.

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3- gamma, - delta and - zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor - CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.

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