Addition of the C‐terminus of CD6 to a chimeric antigen receptor ...
2018年10月9日 · A third-generation CAR containing 4-1BB, CD3ζ and the C terminus of CD6 (4-1BBz-CD6) enhanced interferon-γ release and cytotoxicity when compared with the second …
CD166-specific CAR-T cells potently target colorectal cancer cells
Here, we constructed a CAR based on the extracellular domain of CD6 and demonstrate its cytotoxic effect in target positive human CRC cell lines. Unexpectedly, we found that CD6 …
CD6 as a Cell Surface Receptor and As a Target for Regulating …
CD6 has been exploited as a drug target as its expression is restricted, primarily to T cells, it has a well characterised cell surface ligand, CD166 and regulates T cell activation through a long …
Unlocking the potential of Tregs: innovations in CAR technology
Specificity can be engineered by the addition of chimeric antigen receptors (CARs), with new techniques designed to fine-tune specificity (tandem chimeric antigen receptors, universal …
CD6 and Its Interacting Partners: Newcomers to the Block of
2023年12月15日 · Targeted immunotherapies, such as adoptive transfer of immune cells engineered to express chimeric antigen-specific receptors (CARs), have also gained recent …
Clinical Trials Using Allogeneic Anti-CD6 CAR T-regulatory Cells
This phase I trial tests the safety, side effects, and best dose of allogeneic CD6 chimeric antigen receptor T regulatory cells (CD6-CAR Tregs) in treating patients who have chronic graft versus …
CD6 is a target for cancer immunotherapy - PubMed
2021年3月8日 · The combined capability of an anti-CD6 monoclonal antibody to control autoimmunity through effects on CD4+ lymphocyte differentiation while enhancing killing of …
CD6 and Its Interacting Partners: Newcomers to the Block of …
Unpublished preliminary in vitro observations made by our group using human leukemic NK cell-derived KHYG-1 cells stably transduced with a second-generation CD6-CAR also show …
Allogeneic CD6 Chimeric Antigen Receptor T Regulatory Cells (CD6-CAR …
This phase I trial tests the safety, side effects, and best dose of allogeneic CD6 chimeric antigen receptor T regulatory cells (CD6-CAR Tregs) in treating patients who have chronic graft versus …
allogeneic anti-CD6 CAR T-regulatory cells - National Cancer …
A preparation of allogeneic T-regulatory cells (Tregs) that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the T-cell differentiation antigen CD6, …