CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene …

2019年8月27日 · CHEK2 is a tumor-suppressor gene that protects cells from becoming cancerous. People who inherit mutations in the gene are at increased for certain types of cancer and may benefit from more frequent screening. CHEK2 is the abbreviated name of the gene called checkpoint kinase 2.

2023年7月17日 · A CHEK2 gene mutation increases your risk for certain types of cancers. Your cancer risk may be different depending on the specific CHEK2 mutation you have. Most CHEK2 mutations increase your risk for breast cancer. Some of the most common CHEK2 mutations slightly increase your risk for colorectal (colon and rectal) cancer.

2023年12月19日 · CHEK2 是 “检测点激酶2（checkpoint kinase2）” 基因的缩写。 该基因为血细胞生产CHK2蛋白质提供指令，当细胞里的DNA损毁或DNA链断裂时，CHK2被激活。 CHK2蛋白质有什么作用？ CHK2和其它基因响应DNA损坏的机制如下：通过终止细胞分裂并判断细胞之于人体健康应修复损伤还是自毁。 这一过程确保了具有基因损伤或突变的细胞在分裂时，不会将 “有害” 的DNA传给下一代。 这种基因突变可被视为迈向癌变的第一步。 CHEK2 使得细胞免于癌 …

2024年12月24日 · CHEK2 (Checkpoint Kinase 2) is a Protein Coding gene. Diseases associated with CHEK2 include Tumor Predisposition Syndrome 4 and Prostate Cancer. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

该基因编码的蛋白质是细胞周期检查点调节剂和推定的肿瘤抑制因子。 它包含叉头相关蛋白相互作用结构域，该结构域对于响应 DNA 损伤的激活至关重要，并且响应复制块和 DNA 损伤而迅速磷酸化。 当被激活时，编码的蛋白质已知会抑制 CDC25C 磷酸酶，防止进入有丝分裂，并且已被证明可以稳定肿瘤抑制蛋白 p53，导致细胞周期停滞在 G1 期。 此外，这种蛋白质与 BRCA1 相互作用并磷酸化，使 BRCA1 在 DNA 损伤后恢复存活。 该基因的突变与 Li-Fraumeni 综合征有关， …

2024年6月29日 · An inherited CHEK2 mutation may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.

2025年2月8日 · CHEK2 gene mutations are not associated with differentiated thyroid carcinoma. High CHEK2 expression is associated with trastuzumab-resistant breast cancer. REsults indicate that CHEK2 rare variants, such as duplications, can confer a …

2023年12月11日 · Checkpoint kinase 2 (CHEK2) plays a crucial role in responding to DNA damage and is linked to diverse cancer types. However, its significance in the...

2020年8月24日 · These new guidelines recommend that people with CHEK2 mutations should consider family history and other factors to understand their risk for colorectal cancer and make decisions about their care.