Effective recognition of double-stranded RNA does not require ...
1 天前 · Host sensors differ in their mechanism of dsRNA recognition, recognizing specific dsRNA features or simply detecting the presence of a duplex of ribonucleic acids. RIG-I recognizes …
Cellular origins of dsRNA, their recognition and consequences
2021年11月23日 · Typically, RIG-I is the main cytosolic receptor that senses viral dsRNA, in a manner dependent on m 6 A, while MDA5 also seems to be involved, albeit to a lesser extent 95.
Mechanisms of length-dependent recognition of viral double
2023年4月18日 · Retinoic acid-inducible gene I (RIG-I) is the most front-line cytoplasmic viral RNA sensor and induces antiviral immune responses. RIG-I recognizes...
细胞固有天然免疫信号转导 | Cell Signaling Technology
RIG-1 和 MDA5 等 RIG-I 样受体 (RLR) 能检测双链病毒 RNA 和 5'-三磷酸短 dsRNA。 MDA5 和 RIG-1 会与共有的 caspase 募集结构域相互作用，从而诱导线粒体抗病毒信号转导蛋白 …
Mechanistic modeling explains the dsRNA length-dependent activation of ...
2020年9月7日 · We compare two hypothesized RIG-I binding mechanisms by translating them into mathematical models and analyzing their potential to describe published experimental …
RIG-I and dsRNA-Induced IFNβ Activation - PMC
We have examined a SeV infection whose ability to induce interferon depends on the generation of capped dsRNA (without free 5′ tri-phosphate ends), and found that this infection as well …
吸睛系列 (二)丨一文了解mRNA IVT副产物dsRNA - 知乎
RIG-I和MDA5是两个主要的细胞内病毒dsRNA感受器，一旦识别外源的病毒dsRNA，就会激活抗病毒信号途径，上调干扰素的表达（IFNs）。 RIG-I和MDA5拥有不同的RNA特异性，据此来 …
有效识别双链 RNA 无需激活细胞炎症：解析免疫应答新机制 - 生 …
14 小时之前 · 编辑推荐： 在细胞面对双链 RNA（dsRNA）威胁时，免疫应答机制尚不明确。研究人员开展了 dsRNA 与宿主细胞相互作用的研究，发现有效 dsRNA 应答可不引发炎症，且 5′ …
RNA解旋酶RIG-I在双链RNA诱导的先天抗病毒反应中具有重要功能 …
在本报告中，我们确定了视黄酸诱导型基因I（RIG-I），其编码包含半胱天冬酶募集结构域的DExD / H box RNA解旋酶，作为dsRNA诱导的信号转导的必要调节剂，通过功能筛选和测定进行评估。
PACT prevents aberrant activation of PKR by endogenous dsRNA …
2 天之前 · The antiviral dsRNA sensor PKR is regulated by PACT. This paper shows how PACT prevents aberrant PKR activation by endogenous dsRNAs like Alu. PACT disrupts PKR’s …