2003年4月14日 · We have shown that TLR3 and TRIF function upstream in the signaling pathway leading to the activation of IKKε and TBK1 by dsRNA. IKKε and TBK1 can promote the interaction between...

We examined the molecular mechanism of TLR3 signaling and found that TLR3 stimulation by double-stranded RNA (dsRNA) induces phosphorylation of TRIF at Ser210 and is required for IRF-3 recruitment. TANK-binding kinase 1 (TBK1) is known to be responsible for IRF-3 phosphorylation and activation. KEYWORDS: innate immunity, TRIF, IRF-3, TBK1, IKKβ

TANK 可将上游 RLR 信号转导连接至 TANK 结合激酶 1 (TBK1)，TBK1 会诱导干扰素调节因子 3 (IRF-3) 的磷酸化。 IRF-3 磷酸化和随后的二聚化会诱导 IRF-3 核转位，IRF-3 随后结合干扰素刺激应答元件 (ISRE)，从而导致 I 型干扰素基因表达。

2020年12月3日 · TBK1-mediated phosphorylation of DRP1 was efficient and exhibited a dominant-negative effect, completely eliminating the mitochondrial incision function of DRP1. This TBK1-DRP1 axis was critical for innate RNA sensing and antiviral immunity, and it linked cellular nutrient sensing to mitochondrial dynamics.

2024年2月21日 · We found that DUSP4 regulates the activation of TBK1 and ERK1/2 in a signalling complex containing DUSP4, TBK1, ERK1/2 and IRF3 to regulate the production of type I IFNs. Mice deficient in...

2016年7月1日 · Phosphatase PPM1A is a natural component of TBK1/IKKε kinase complex, which is recruited by kinase domains of TBK1/IKKε to restrain cytosolic RNA sensing by directly dephosphorylating both MAVS and TBK1/IKKε, potentially …

2021年8月1日 · To investigate a role for TBK1 and mTOR P-S2159 in positive control of mTORC2 signaling in macrophages, we assessed how TBK1/IKKε inhibitors or Mtor S2159A knock-in modulated mTORC2 signaling to Akt in response to TLR3 …

2019年5月23日，德克萨斯A & M大学生物化学与生物物理系李平卫团队在Nature期刊上发表文章A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1，揭示了STING蛋白C末端上PLPLRT/SD基序介导了TBK1的招募和激活。

2021年8月15日 · Nuclear-derived dsRNA is packaged into extracellular vesicles and subsequently recognized by toll-like receptor 3 (TLR3) to activate TBK1 and downstream MHC class I expression in an autocrine or paracrine manner before being degraded in lysosomes. MYC suppressed loading of dsRNA onto TLR3 and its subsequent …

2025年3月19日 · In endosome, TLR3 detects dsRNA and initiates signaling through TRIF, TRAF3 and IRF3 to induce type I IFNs as well as via TRIF, TRAF6, MAPK and NF-κB to the production of proinflammatory cytokines.