Insights into the dynamic nature of the dsRNA-bound TLR3 complex
2019年3月6日 · TLR3, a well-studied TLR, is localized on endosomes and detects double-stranded RNA (dsRNA) released from viruses during invasion or necrotic cells during …
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in ...
After double-stranded RNA (dsRNA) activates endosomal TLR3, TRIF transiently colocalizes with TLR3; it dissociates from the receptor and forms a speckle-like structure that relocalizes with …
dsRNA-Activation of TLR3 and RLR Signaling: Gene Induction …
TLR3 recognizes extracellular dsRNA released from damaged tissues or virus-infected cells. TLR3 activation by dsRNA leads to direct induction of antiviral genes in virus-infected cells. …
The toll-like receptor 3:dsRNA signaling complex - PubMed
Toll-like receptors (TLRs) recognize conserved molecular patterns in invading pathogens and trigger innate immune responses. TLR3 recognizes dsRNA, a molecular signature of most …
TLR3: Interferon induction by double-stranded RNA including poly…
2008年4月29日 · Identification of the TLR3-TICAM-1-mediated signaling cascades different from those of RIG-I/MDA5, ligand repertoire of TLR3, and dsRNA transport system provides new …
TLR3 forms a highly organized cluster when bound to a poly (I
2022年11月12日 · Here, we report the structure of a TLR3 cluster induced by the binding of a long dsRNA ligand. By mixing full-length TLR3 with poly (I:C) RNA, we form TLR3-dsRNA …
The dsRNA binding site of human Toll-like receptor 3 - PNAS
2006年6月6日 · The pivotal roles played by H539 and N541 in ligand recognition suggest that dsRNA interacts with TLR3 on the glycan-free lateral surface and predicts that glycans are not …
Small-molecule inhibitors of the TLR3/dsRNA complex - PubMed
2011年3月23日 · The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the …
pH‐Dependent Assembly and Stability of Toll‐Like Receptor 3/dsRNA …
2024年11月8日 · Investigate the pH-dependent assembly of the TLR3/dsRNA signaling complex. Highlights the histidines functions as pH-dependent, positively charged binding site, and …
TLR3 forms a laterally aligned multimeric complex along double
2023年1月11日 · Here, we report cryo-electron microscopy analyses of TLR3 complexed with longer dsRNA. TLR3 dimers laterally form a higher multimeric complex along dsRNA, …