E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4 …

The E2F family can be divided into four subgroups based on their potential main function and the mechanism by which this is achieved. E2Fs 1–3, the ‘activating' E2Fs, are required for the …

该调控轴的最终效应子是编码转录激活因子和抑制因子的8个不同 E2F 基因家族的成员（E2F1-8）。 E2F 转录活性在整个细胞周期中通过转录和翻译调控、翻译后修饰、蛋白质降解、与辅 …

Among E2F genes, the E2F3 and E2F7 loci can undergo two alternative splicing events to encode four protein isoforms: E2F3a, E2F3b, E2F7a, and E2F7b (29–31). The E2F family can be …

2020年3月5日 · Here we find that a mammalian circadian rhythm component, Cryptochrome 2 (CRY2), regulates E2F family members. Furthermore, CRY1 and CRY2 cooperate with the E3 …

E2F is a heterodimer composed of two partners, such as E2F1 and DP1. Although E2F1 can bind DNA as a homodimer and increase promoter activity, optimal DNA-binding and transcriptional …

2004年12月8日 · The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding …

2021年8月12日 · The E2F family of transcription factors (E2Fs) consist of eight genes in mammals. These genes encode ten proteins that are usually classified as transcriptional …

2002年6月4日 · There are six published members of the E2F family that are divided into three sub-groups based upon sequence homology and domain organization. Each E2F subunit has …

2009年3月1日 · Atypical E2F proteins represent an evolutionarily conserved branch of the E2F TFs family, in which the presence of a duplicated DBD provides these new E2F players with …