Elongation factor 1-alpha 1 (eEF1a1) is a translation elongation protein, expressed across eukaryotes. In humans, it is encoded by the EEF1A1 gene. [5][6] This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome.

真核生物的eef1a相当于原核的ef-tu，eef1b相当于ef-ts，起交换因子作用。而在成键阶段，原核生物需要延伸因子p（ef-p），真核生物则是eif5a（曾用名为eif-4d）。 最初认为eif5a参与翻译起始或第一肽键形成，所以命名为if。

2010年7月9日 · Eukaryotic translation elongation factor 1A (eEF1A) is one of the most abundant protein synthesis factors. eEF1A is responsible for the delivery of all aminoacyl-tRNAs to the ribosome, aside from initiator and selenocysteine tRNAs. In addition to its roles in polypeptide chain elongation, unique cel …

Eukaryotic translation elongation factor 1A (eEF1A) is one of the most abundant protein synthesis factors. eEF1A is responsible for the delivery of all aminoacyl-tRNAs to the ribosome, aside from initiator and selenocysteine tRNAs.

eEF1A是真核生物体内除肌动蛋白之外含量第二多的蛋白，占总蛋白量的1%～3%，且具有高度保守性。 不同生物的eEF1A序列相似，其生物学功能也非常相似 [2]。 在细菌体内它又称为EF-Tu。 eEF1A含有三个空间构象和功能都不同的结构域：domain I，II，III，其中Domain I与GTP结合，Domain II与酰基-tRNA结合，domainII 和domain III还共同参与和细胞内的肌动蛋白的结合 [3]。 蛋白质的翻译是一个非常复杂的过程，需要多种因子的参与才能完成，主要可分为起始、延长 …

2023年1月1日 · The eEF1 family of mammalian translation elongation factors is comprised of the two variants of eEF1A (eEF1A1 and eEF1A2), and the eEF1B complex. The latter consists of eEF1Bα, eEF1Bβ, and eEF1Bγ subunits. The two eEF1A variants have similar translation activity but may differ with respect to their secondary, “moonlighting” functions.

2024年12月24日 · EEF1A1 (Eukaryotic Translation Elongation Factor 1 Alpha 1) is a Protein Coding gene. Diseases associated with EEF1A1 include Eukaryotic Translation Elongation Factor 1 Alpha-1-Like 14 and Lice Infestation. Among its related pathways are Peptide chain elongation and Infectious disease.

2015年4月7日 · This review summarizes the recent findings on eEF1A proteins indicating that eEF1A proteins play a critical role in numerous human diseases through enhancement of oncogenesis, blockade of apoptosis, and increased viral pathogenesis.

2025年2月7日 · Plitidepsin is an antitumoral compound safe for treating COVID-19 that targets the translation elongation factor eEF1A. Here we detect that plitidepsin decreases de novo cap-dependent translation...

真核延长因子( eEFs)是一类在蛋白质合成过程中发挥肽链延伸作用的重要分子,在真核生物体内它有eEF1和eEF2两个亚型.其中在肽链延伸过程中起主要作用的eEF1A是eEF1的一个亚型,它不但能促进氨酰基-tRNA( aa-tRNA)与核糖体的A位点结合,发挥肽链延伸功能；而且近年来 ...