EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR
2022年11月7日 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required …
Phosphoglycerate kinase 1 acts as a cargo adaptor to promote EGFR ...
2024年2月3日 · Here, we find that phosphoglycerate kinase 1 (PGK1) is recruited to endosomal membrane upon its phosphorylation, where it binds to the dileucine sorting signal in EGFR to …
A MYC-STAMBPL1-TOE1 positive feedback loop mediates EGFR
2024年10月22日 · Here, we report the functions of STAMBPL1 in modulating the stability of the protein and mRNA of the epidermal growth factor receptor (EGFR). STAMBPL1 deficiency …
Time-resolved proximity labeling of protein networks associated …
2022年6月14日 · On the other hand, proteins known to reside in late endosomes and lysosomes, such as LAMP1, LAMTOR1, and VTI1B, were found to be enriched in close proximity to EGFR …
Targeting of EGFR by a combination of antibodies mediates ...
2020年1月20日 · Next, we analysed the kinetics of EGFR delivery to LEs/MVBs and found a sharp increase in EGFR colocalisation with LAMP1 (lysosome-associated membrane protein …
O-GlcNAcylation regulates epidermal growth factor receptor ...
Epidermal growth factor receptor (EGFR) is one of the most important membrane receptors that transduce growth signals into cells to sustain cell growth, proliferation, and survival. EGFR …
Sialylation of EGFR by ST6GAL1 induces receptor activation and ...
2023年10月1日 · To assess lysosomal colocalization, we treated cells with EGF for 60 min and costained cells for EGFR and the lysosomal marker, LAMP1 (37). In this case, OE cells had …
唐靖/刘志峰团队合作利用磷酸化组和代谢组揭示脓毒症中EGFR胞 …
2022年11月29日 · 为研究S72磷酸化对Rab7a的GTPase活性的影响，作者分析了LPS处理的巨噬细胞中， Rab7a与CD63 (晚期核内体)、LAMP1 (自噬体成熟阶段相关蛋白)的共定位（图3E …
Endosomal Arl4A attenuates EGFR degradation by binding to the …
Antibodies against EEA1 (early endosomes) and Lamp1 (late endosomes/lysosomes) were used to track the trafficking of internalized EGFR (Supplementary Fig. 2a, b). Compared with control …
Endosomal Type Iγ PIP 5-Kinase Controls EGF Receptor
2013年4月29日 · The integrated voxel intensity of EGFR in the segmented image was considered as EGFR localized in EEA1- or LAMP1-labeled vesicles, respectively. The extent of …