MUC1 stimulates EGFR expression and function in endometrial …
2016年5月31日 · We show for the first time that MUC1 stimulates EGFR expression and function in endometrial cancer. siRNA knockdown and CRISPR/Cas knockout of MUC1 reduced EGFR …
Abstract 6325: A novel EGFR x MUC1 bispecific antibody-drug …
2023年4月4日 · Internalization assays demonstrate that the anti-EGFR/MUC1 bispecific antibody used to generate BSA01 was endocytosed in tumor cells co-expressing EGFR/MUC1 more …
EGFR and MUC1 as dual-TAA drug targets for lung cancer and
2024年11月27日 · Results: A candidate TAA target, transmembrane glycoprotein mucin 1 (MUC1), showed strong expression in cancer cells and low expression in normal cells. Single …
A narrative review of antibody–drug conjugates in EGFR-mutated …
Epidermal growth factor receptor (EGFR) was the first mutation in NSCLC to have a drug that was FDA-approved in 2013. Osimertinib, a third-generation tyrosine kinase inhibitor, is approved …
AACR 2023: A Novel EGFR x MUC1 Bispecific Antibody-Drug
2023年4月19日 · BSA01 is an EGFR- and MUC-1-targeting bsADC derived from the proprietary, RenLite® common light chain, fully human antibody mouse platform. BSA01 binds to MUC1 …
1164 BSA01, a bispecific antibody-drug conjugate targeting EGFR …
To overcome limitations of current EGFR- and MUC-1-targeting therapies, we generated a novel bispecific antibody-drug conjugate conjugated with monomethyl auristatin E, BSA01, which …
Preclinical studies of the bispecific MUC1xEGFR antibody drug …
MUC1 and EGFR were consistently expressed in NSCLC tumors after EGFR-TKI relapse. These findings indicate that NSCLC patients developing EGFR-TKI resistance under treatment may …
Targeting the oncogenic MUC1-C protein inhibits mutant EGFR …
2014年11月1日 · These findings indicate that targeting MUC1-C inhibits mutant EGFR signaling and survival, and thus represents a potential approach alone and in combination for the …
MUC1: An emerging target in cancer treatment and diagnosis
2022年11月1日 · MUC1-C/ED is a recognition site for the Epidermal Growth Factor receptor (EGFR) and other receptor kinases. MUC1-C/TMD assists MUC1 in anchoring to the cell …
MUC1 stimulates EGFR expression and function in endometrial …
We show for the first time that MUC1 stimulates EGFR expression and function in endometrial cancer. siRNA knockdown and CRISPR/Cas knockout of MUC1 reduced EGFR gene …