Eukaryotic initiation factor 3 - Wikipedia
Eukaryotic initiation factor 3 (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic translation. [2] It is essential for most forms of cap-dependent and cap-independent translation initiation.
EIF3 - 百度百科
eIF3（eukaryotic initiation factor 3，真核起始因子3）是最大的 真核起始因子，在 哺乳动物细胞 中，其 分子量 超过了600KDa。 eIF3是真核翻译起始进程中起着核心作用。 例如，eIF3可以使eIF2·GTP·Met- tRNA i三联体复合物稳定地结合到40S 核糖体亚基 上，并促使43S前起始复合物的形成；它能够通过促进 mRNA 与40S亚基结合；而且，它还可以与游离的40S亚基结合，影响40S亚基与60S亚基及其他eIF的结合或解离等等。 eIF3是一个结构中心，可以与不同的 真核 …
真核起始因子3 - 维基百科，自由的百科全书
eIF3 （eukaryotic initiation factor 3，真核起始因子3）是最大的 真核起始因子，在 哺乳动物 细胞中，其 分子量 超过了600KDa。 eIF3是 真核翻译 起始进程中起着核心作用。 [1] 例如，eIF3可以使 eIF2 · GTP ·Met- tRNA i 三联体复合物稳定地结合到40S 核糖体 亚基上，并促使43S前起始复合物的形成；它能够通过促进 mRNA 与40S亚基结合；而且，它还可以与游离的40S亚基结合，影响40S亚基与60S亚基及其他eIF的结合或解离等等。 [2] eIF3是一个结构中心，可以与不同的真 …
eIF3: a factor for human health and disease - PMC - PubMed …
The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal ...
eIF3a function in immunity and protection against severe sepsis by ...
2025年2月11日 · eIF3a is a N6 -methyladenosine (m 6 A) reader that regulates mRNA translation by recognizing m 6 A modifications of these mRNAs. It has been suggested that eIF3a may play an important role in regulating translation initiation via m 6 A during infection when canonical cap-dependent initiation is inhibited.
eIF3: a factor for human health and disease - PubMed
2018年1月2日 · The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling.
eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant ...
2023年6月15日 · eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNA-selective functions of individual subunits remain poorly defined. Using multiomic profiling upon acute depletion of eIF3 subunits, we observed that while eIF3a, b, e, and …
清华大学生命学院杨雪瑞与厦门大学Dieter Wolf合作发现eIF3促进 …
2020年6月30日 · eIF3在翻译起始、延伸和新生蛋白靶向过程中的作用模型. 本论文揭示了真核生物翻译过程中重要的起始因子家族eIF3的新功能，并利用eIF3e缺陷小鼠模型证明eIF3对维持线粒体的生理功能和小鼠肌肉健康具有重要意义。
eIF3: a versatile scaffold for translation initiation complexes
Translation initiation in eukaryotes depends on many eukaryotic initiation factors (eIFs) that stimulate both recruitment of the initiator tRNA, Met-tRNA (i) (Met), and mRNA to the 40S ribosomal subunit and subsequent scanning of the mRNA for the AUG start codon.
程亚彬与合作团队发现eIF3选择性调控mRNA翻译新功能
2023年6月29日 · 近日，药学院程亚彬助理教授与西湖大学Dieter A. Wolf教授及厦门弘爱医院孔祥泉教授合作在EMBO Journal上发表题为“eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome...