We investigated the incidence of eukaryotic translation initiation factor 3 subunit H (EIF3H) and MYC amplification in non-small cell lung cancer (NSCLC) patients, and whether MYC/EIF3H increased gene copy number affected response to Epidermal Growth Factor Receptor tyrosine kinase inhibitors.

Overall, our findings suggest that eIF3m inhibition significantly suppressed PCa cell growth and c-Myc signaling, indicating that eIF3m is a promising therapeutic target for PCa patients.

2023年9月28日 · Here we show that the EIF3A HLH motif controls translation of a small set of cellular transcripts enriched in oncogenic mRNAs, including MYC. We demonstrate that the HLH motif of EIF3A acts specifically on the 5′ UTR of MYC mRNA and modulates the function of EIF4A1 on select transcripts during translation initiation. In Ramos lymphoma cell ...

2023年6月29日 · 近日，药学院程亚彬助理教授与西湖大学 Dieter A. Wolf 教授 及 厦门弘爱医院孔祥泉教授 合作 在 EMBO Journal 上发表题为“ eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content” 的研究论文，揭示了 eIF3 新的...

2023年9月28日 · Here we show that the EIF3A HLH motif controls translation of a small set of cellular transcripts enriched in oncogenic mRNAs, including MYC. We demonstrate that the HLH motif of EIF3A acts specifically on the 5′ UTR of MYC mRNA and modulates the function of EIF4A1 on select transcripts during translation initiation.

Background: We investigated the incidence of eukaryotic transla-tion initiation factor 3 subunit H (EIF3H) and MYC amplification in non-small cell lung cancer (NSCLC) patients, and whether MYC/ EIF3H increased gene copy number affected response to Epidermal Growth Factor Receptor tyrosine kinase inhibitors.

2018年10月5日 · eIF3 is the most complex mammalian initiation factor and plays a pivotal role in protein synthesis. Knowledge of eIF3 is to provide new diagnostic and therapeutic options of cancers. Abnormal regulation of gene expression is essential for tumorigenesis.

By differentially prioritizing mRNA translation, stress granules allow for the continued and selective translation of stress response proteins. Although the multi-subunit eukaryotic initiation factor 3 (eIF3) is required for translation initiation, its …

The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal ...

Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues. 启用核糖体结合活性。 有助于翻译起始因子活动。 参与 mRNA 结合活性的正向调节；翻译的积极调节；和翻译启动。 真核翻译起始因子 3 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月] Enables ribosome binding activity. Contributes to translation initiation factor activity.