eIF3: A ConnecTOR of S6K1 to the Translation Preinitiation …
2005年12月9日 · After confirming the interaction between endogenous S6K1 and eIF3, the authors set upon uncovering potential mechanisms that regulate this interaction. They found …
eIF3 controls cell size independently of S6K1-activity
2015年9月9日 · Here, we challenged cell size control through S6K1 by specifically depleting its binding partner eIF3 in normal and transformed cell lines. We show that loss of eIF3 leads to a …
eIF3a regulation of mTOR signaling and translational control via …
2022年3月12日 · Here, we show that eIF3a regulates S6K1 activity by inhibiting mTORC1 kinase via regulating Raptor synthesis. The regulation of Raptor synthesis is via eIF3a interaction with …
mTOR and S6K1 Mediate Assembly of the Translation Preinitiation …
2005年11月18日 · We show that mTOR and S6K1 maneuver on and off the eukaryotic initiation factor 3 (eIF3) translation initiation complex in a signal-dependent, choreographed fashion. …
eIF3a regulation of mTOR signaling and translational control via …
S6K1 is an effector and a mediator of mTOR complex 1 (mTORC1) in regulating protein synthesis and integrating diverse signals into control of cell growth and response to stress. Here, we …
eIF3 family members as S6K1 interactors represented a potentially important connection between the mTOR pathway and an integral component of the translational preinitiation apparatus. …
eIF3: a connecTOR of S6K1 to the translation preinitiation complex
2005年12月9日 · In the November 18 issue of Cell, discover an unidentified function for the eIF3 translation initiation factor as a scaffold for the dynamic associations of many preinitiation …
eIF3: A ConnecTOR of S6K1 to the Translation Preinitiation Complex
2005年12月9日 · After confirming the interaction between endogenous S6K1 and eIF3, the authors set upon uncovering potential mechanisms that regulate this interaction. They found …
The Translation Regulatory Subunit eIF3f Controls the Kinase …
During terminal muscle differentiation a conserved TOS motif in eIF3f connects mTOR/raptor complex, which phosphorylates S6K1 and regulates downstream effectors of mTOR and Cap …
mTOR and S6K1 mediate assembly of the translation ... - PubMed
2005年11月18日 · We show that mTOR and S6K1 maneuver on and off the eukaryotic initiation factor 3 (eIF3) translation initiation complex in a signal-dependent, choreographed fashion. …