Critical and differential roles of eIF4A1 and eIF4A2 in B-cell ...
2024年11月8日 · Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by forming the cap-binding eIF4F complex,...
eIF4A - 维基百科，自由的百科全书
真核起始因子 4A （英語： eukaryotic translation Initiation Factor 4A，简称为 eIF4A）是一种 ATP 依赖性 RNA 结合蛋白，一种RNA依赖性 ATP酶，和一种RNA 解旋酶，它在 真核翻译 起始进 …
Topology and Regulation of the Human eIF4A/4G/4H Helicase …
2009年2月6日 · Here we report the topology of the eIF4A/4G/4H helicase complex, which is built from multiple experimentally observed domain-domain contacts. Remarkably, some of the …
eIF4B, eIF4G and RNA regulate eIF4A activity in translation …
Eukaryotic translation initiation factor eIF4A is a DEAD-box helicase that resolves secondary structure elements in the 5'-UTR of mRNAs during ribosome scanning. Its RNA-stimulated …
Cell Mol Immunol. | Polysome技术助力揭示eIF4A异构体的作用新 …
2024年11月28日 · 导读：真核起始因子4a （Eukaryotic initiation factor 4a, eIF4A）通过形成帽结合eIF4F复合物、募集40S小核糖体亚基、扫描5’ UTR寻找起始密码子，在细胞mRNA的翻译 …
NAR︱哥伦比亚大学王建龙团队揭示eIF4A3介导的转录后调控在胚 …
2022年11月23日，美国哥伦比亚大学欧文医学中心（Columbia University Irving Medical Center） 王建龙 教授团队在 Nucleic Acids Research 杂志在线发表了题为 “An RNAi screen of RNA …
Frontiers | Expression and Functional Roles of Eukaryotic Initiation ...
2021年11月18日 · Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and act as RNA-dependent ATPases.
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A …
2020年1月9日 · We demonstrate that, through ATP-dependent RNA binding, the DEAD-box protein eIF4A reduces RNA condensation in vitro and limits stress granule formation in cells. …
eIF4B, eIF4G and RNA regulate eIF4A activity in translation ... - PubMed
We show here that eIF4A alone does not measurably sample the closed conformation. The translation initiation factors eIF4B and eIF4G accelerate the eIF4A conformational cycle. …
真核翻译起始因子4A研究进展与展望 - 豆丁网
2016年3月15日 · 摘要:真核翻译起始因子4a(eif4a)蛋白属于dead－boxRna解旋酶家族，具有Rna依赖的atp酶活性和atp依赖的Rna解旋酶活性。脊椎动物中已经鉴定出三种eif4a:eif4a1 …