
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell ...
2024年11月8日 · Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by forming the cap-binding eIF4F complex,...
eIF4A - 维基百科,自由的百科全书
真核起始因子 4A (英語: eukaryotic translation Initiation Factor 4A,简称为 eIF4A)是一种 ATP 依赖性 RNA 结合蛋白,一种RNA依赖性 ATP酶,和一种RNA 解旋酶,它在 真核翻译 起始进程中发挥重要作用。 它被认为可以解开 mRNA 的 5'端 非翻译区的二级和三级结构,以使 核糖体 的附着更容易,同时允许核糖体进行 起始密码子 扫描。 [1] eIF4A在人体中有三个亚型:eIF4A-1、eIF4A-2和eIF4A-3。 eIF4A是 DEAD盒 RNA解旋酶超家族成员,其 氨基酸 序列中具有8个保守 …
Topology and Regulation of the Human eIF4A/4G/4H Helicase …
2009年2月6日 · Here we report the topology of the eIF4A/4G/4H helicase complex, which is built from multiple experimentally observed domain-domain contacts. Remarkably, some of the interactions are continuously rearranged during the ATP binding/hydrolysis cycle of the helicase.
eIF4B, eIF4G and RNA regulate eIF4A activity in translation …
Eukaryotic translation initiation factor eIF4A is a DEAD-box helicase that resolves secondary structure elements in the 5'-UTR of mRNAs during ribosome scanning. Its RNA-stimulated ATPase and ATP-dependent helicase activities are enhanced by other ...
Cell Mol Immunol. | Polysome技术助力揭示eIF4A异构体的作用新 …
2024年11月28日 · 导读:真核起始因子4a (Eukaryotic initiation factor 4a, eIF4A)通过形成帽结合eIF4F复合物、募集40S小核糖体亚基、扫描5’ UTR寻找起始密码子,在细胞mRNA的翻译起始过程中发挥关键作用。
NAR︱哥伦比亚大学王建龙团队揭示eIF4A3介导的转录后调控在胚 …
2022年11月23日,美国哥伦比亚大学欧文医学中心(Columbia University Irving Medical Center) 王建龙 教授团队在 Nucleic Acids Research 杂志在线发表了题为 “An RNAi screen of RNA helicases identifies eIF4A3 as a regulator of embryonic stem cell identity” 的研究论文 [2]。 该论文从RNA解旋酶两大家族Ddx/Dhx基因中筛选并发现了eIF4A3(又名Ddx48)调控胚胎干细胞的稳态维持,并深入阐明了eIF4A3介导的转录后调控特异性细胞周期基因以维持胚胎干细胞多能性 …
Frontiers | Expression and Functional Roles of Eukaryotic Initiation ...
2021年11月18日 · Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and act as RNA-dependent ATPases.
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A …
2020年1月9日 · We demonstrate that, through ATP-dependent RNA binding, the DEAD-box protein eIF4A reduces RNA condensation in vitro and limits stress granule formation in cells. This defines a function for eIF4A to limit intermolecular RNA-RNA interactions in cells.
eIF4B, eIF4G and RNA regulate eIF4A activity in translation ... - PubMed
We show here that eIF4A alone does not measurably sample the closed conformation. The translation initiation factors eIF4B and eIF4G accelerate the eIF4A conformational cycle. eIF4G increases the rate of closing more than the opening rate, …
真核翻译起始因子4A研究进展与展望 - 豆丁网
2016年3月15日 · 摘要:真核翻译起始因子4a(eif4a)蛋白属于dead-boxRna解旋酶家族,具有Rna依赖的atp酶活性和atp依赖的Rna解旋酶活性。脊椎动物中已经鉴定出三种eif4a:eif4a1、eif4a2和eif4a3。除参与翻译起始,eif4a家族成员在胚胎发育等多种生命过程中也发挥着重要的作 …