2024年11月8日 · Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by forming the cap-binding eIF4F complex, recruiting...

Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay processes …

2019年2月19日 · Ryu et al. show that eIF4A3 (a core EJC component) is phosphorylated at the threonine 163 position by CDK1 and CDK2 in a cell cycle-dependent manner. This event …

The overall topology of the human eIF4A-I/eIF4G/eIF4H complex has been dissected in a combination of NMR, mutational and binding studies. 53 Interactions were identified between …

2017年7月21日 · No small molecules for NMD inhibition via selective inhibition of eIF4A3 have been discovered. Here, we identified allosteric eIF4A3 inhibitors from a high-throughput …

In this review, we explored the predicted structures of the three eIF4A isoforms (eIF4A1, eIF4A2, and eIF4A3), and discussed possible explanations for which function during different …

2021年11月19日 · Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and act as RNA-dependent ATPases. In this …

EIF4A3, a member of the DEAD-box protein family, is a nuclear matrix protein and a core component of the exon junction complex (EJC). Under physiological conditions, EIF4A3 …

2021年6月6日 · Here, we present the first crystal structure of an eIF4A1:RNA complex bound to an analogue of the marine sponge-derived natural product PatA, C5-desmethyl pateamine A …

2025年2月2日 · Inhibition of eIF4A3 activity abolished UPF1 binding to NMD transcripts. Nonsense-Mediated mRNA Decay (NMD) is a key control mechanism of RNA quality widely …