eIF4A - 维基百科，自由的百科全书
真核起始因子4A（英語： eukaryotic translation Initiation Factor 4A ，简称为eIF4A）是一种ATP依赖性RNA结合蛋白，一种RNA依赖性ATP酶，和一种RNA解旋酶，它在真核翻译起始 …
eIF4A - Wikipedia
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal …
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell ...
2024年11月8日 · While eIF4A1 controls global protein synthesis, eIF4A2 regulates the biogenesis of 18S ribosomal RNA and the 40S ribosome subunit. This study demonstrates the distinct …
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A …
2020年1月9日 · We demonstrate that, through ATP-dependent RNA binding, the DEAD-box protein eIF4A reduces RNA condensation in vitro and limits stress granule formation in cells. …
The DEAD-box helicase eIF4A1/2 acts as RNA chaperone during
5 天之前 · Tauber, D. et al. Modulation of RNA Condensation by the DEAD-Box Protein eIF4A. Cell 180 , 411–426.e416 (2020). Article CAS PubMed PubMed Central MATH Google Scholar
Discovery of RNA-Protein Molecular Clamps Using Proteome …
4 天之前 · We apply our approach to rocaglates, molecules that specifically clamp RNA to eukaryotic translation initiation factor 4A (eIF4A), DEAD-box helicase 3X (DDX3X), and …
NAR | 揭秘eIF4F和eIF4B如何助力闭环结构完成翻译终止任务
2 天之前 · 导读. eif4f复合物 （eif4e、eif4g、eif4a）在帽依赖性翻译起始中至关重要。 eif4e识别5′帽结构，eif4a作为rna解旋酶，eif4g作为支架蛋白，与eif3结合促进48s pic组装。eif4a …
Cell Mol Immunol. | Polysome技术助力揭示eIF4A异构体的作用新 …
2024年11月28日 · eIF4A1 控制全局蛋白合成，而eIF4A2调节18Sr RNA 和40S核糖体亚基的生物发生。 本研究揭示了eIF4A1和eIF4A2不同的细胞和分子功能，并揭示了eIF4A2在控制40S核 …
Eukaryotic initiation factors eIF4F and eIF4B promote translation ...
5 天之前 · Introduction. Eukaryotic translation initiation factor 4F (eIF4F) is required for the preinitiation complex (PIC) assembly at capped messenger RNA (mRNA) and the subsequent …
RCSB PDB - 9DTS: Crystal structure of the human …
2024年10月1日 · Eukaryotic initiation factor 4A-1 (eIF4A1) is an ATP-dependent RNA helicase that unwinds 5'-UTR mRNA secondary structures to facilitate cap-dependent translation …