eIF4A - 维基百科，自由的百科全书
真核起始因子4A（英語： eukaryotic translation Initiation Factor 4A ，简称为eIF4A）是一种ATP依赖性RNA结合蛋白，一种RNA依赖性ATP酶，和一种RNA解旋酶，它在真核翻译起始进程中发挥重要作用。
eIF4A - Wikipedia
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA .
Critical and differential roles of eIF4A1 and eIF4A2 in B-cell ...
2024年11月8日 · While eIF4A1 controls global protein synthesis, eIF4A2 regulates the biogenesis of 18S ribosomal RNA and the 40S ribosome subunit. This study demonstrates the distinct cellular and molecular...
Modulation of RNA Condensation by the DEAD-Box Protein eIF4A …
2020年1月9日 · We demonstrate that, through ATP-dependent RNA binding, the DEAD-box protein eIF4A reduces RNA condensation in vitro and limits stress granule formation in cells. This defines a function for eIF4A to limit intermolecular RNA-RNA interactions in cells.
The DEAD-box helicase eIF4A1/2 acts as RNA chaperone during
5 天之前 · Tauber, D. et al. Modulation of RNA Condensation by the DEAD-Box Protein eIF4A. Cell 180 , 411–426.e416 (2020). Article CAS PubMed PubMed Central MATH Google Scholar
Discovery of RNA-Protein Molecular Clamps Using Proteome …
4 天之前 · We apply our approach to rocaglates, molecules that specifically clamp RNA to eukaryotic translation initiation factor 4A (eIF4A), DEAD-box helicase 3X (DDX3X), and potentially other members of the DEAD-box (DDX) helicase family. To identify unexpected interactions, we used a target class-specific thermal window and compared ATP analog and RNA ...
NAR | 揭秘eIF4F和eIF4B如何助力闭环结构完成翻译终止任务
2 天之前 · 导读. eif4f复合物 （eif4e、eif4g、eif4a）在帽依赖性翻译起始中至关重要。 eif4e识别5′帽结构，eif4a作为rna解旋酶，eif4g作为支架蛋白，与eif3结合促进48s pic组装。eif4a受eif4b增强解旋活性，pabp通过eif4g促进闭环结构形成，提高翻译效率。
Cell Mol Immunol. | Polysome技术助力揭示eIF4A异构体的作用新 …
2024年11月28日 · eIF4A1 控制全局蛋白合成，而eIF4A2调节18Sr RNA 和40S核糖体亚基的生物发生。 本研究揭示了eIF4A1和eIF4A2不同的细胞和分子功能，并揭示了eIF4A2在控制40S核糖体生物发生中的新作用。 标题： Critical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function. 发表期刊： Cellular & Molecular Immunology. 发表时间： 2024. 11. 作者团队：厦门大学肖昌春教授团队. IF：21.8. DOI： 10.1038/s41423-024-01234-x.
Eukaryotic initiation factors eIF4F and eIF4B promote translation ...
5 天之前 · Introduction. Eukaryotic translation initiation factor 4F (eIF4F) is required for the preinitiation complex (PIC) assembly at capped messenger RNA (mRNA) and the subsequent scanning []. eIF4F consists of eIF4G, eIF4E, and eIF4A [], each of them performs a specific function in translation initiation. eIF4G is a scaffold protein which binds the other two subunits [].
RCSB PDB - 9DTS: Crystal structure of the human …
2024年10月1日 · Eukaryotic initiation factor 4A-1 (eIF4A1) is an ATP-dependent RNA helicase that unwinds 5'-UTR mRNA secondary structures to facilitate cap-dependent translation initiation. ... EIF4A1, DDX2A, EIF4A EC: 3.6.4.13: UniProt & NIH Common Fund Data Resources: Find proteins for P60842 (Homo sapiens) Explore P60842 . Go to UniProtKB: P60842. PHAROS ...