eIF4B, eIF4G and RNA regulate eIF4A activity in translation …
Eukaryotic translation initiation factor eIF4A is a DEAD-box helicase that resolves secondary structure elements in the 5'-UTR of mRNAs during ribosome scanning. Its RNA-stimulated …
Disordered regions of human eIF4B orchestrate a dynamic self
2024年10月10日 · Specifically within this latter category of proteins is eIF4B, the major portion of which is predicted to be intrinsically disordered (Fig. 1a, b). eIF4B is essential for optimal …
NAR | 揭秘eIF4F和eIF4B如何助力闭环结构完成翻译终止任务
1 天前 · 七. mRNA的Poly(A)尾增加了eIF4G1、eIF4A和eIF4B对翻译终止的刺激作用. 研究表明，PABP增强eIF4G1、eIF4A和eIF4B在翻译终止中的活性，尤其是在poly(A)尾存在时。 …
Eukaryotic initiation factors eIF4F and eIF4B promote translation ...
4 天之前 · Specifically, eIF4A and eIF4B promote the loading of eRF1 into the A site of the ribosome, while eIF4G1 stimulates the GTPase activity of eRF3 and facilitates the dissociation …
eIF4B stimulates eIF4A ATPase and unwinding activities by direct ...
2017年1月2日 · Here we show that eIF4B binds to eIF4A in the presence of RNA and ADPNP, independent of the presence of eIF4G. A stretch of seven moderately conserved repeats, the …
The structure of a human translation initiation complex reveals two ...
2024年1月29日 · The structure identifies the interaction of eIF4B with the entry site bound eIF4A, providing insight into its role in regulating this second eIF4A rather than eIF4F during scanning.
The DEAD-box helicase eIF4A1/2 acts as RNA chaperone during
4 天之前 · To further investigate the interplay of eIF4A-helicases and ... B. C. & Fraser, C. S. Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by …
eIF4B controls survival and proliferation and is regulated by proto ...
2010年10月10日 · Recent studies have shown that eIF4B is phosphorylated and activated by Ras-MAPK and PI3K-mTOR signaling cascades. In addition, eIF4B regulates translation of …
Eukaryotic initiation factor 4B and the poly(A)-binding protein …
In this study, we show that eIF4G differs from eIFiso4G in that it contains two distinct interaction domains for the poly(A) binding protein (PABP) and eIF4B but is similar to eIFiso4G in having …
Eukaryotic initiation factor 4B is a multi-functional RNA binding ...
2024年9月3日 · We have investigated the role of eukaryotic initiation factor 4B (eIF4B) in this process and identify 10-fold more RNA binding sites for eIF4B in tumour cells from patients …
- 某些结果已被删除