2024年12月24日 · EIF4B (Eukaryotic Translation Initiation Factor 4B) is a Protein Coding gene. Diseases associated with EIF4B include Mouth Disease and Schinzel-Giedion Midface Retraction Syndrome. Among its related pathways are Peptide chain elongation and Translation Insulin regulation of translation.

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene. [5] eIF4B has been shown to interact with and stimulate the activity of eIF4A and bind to the eIF3 complex through the eIF3A subunit. [6] .

2024年10月10日 · This study reveals how the intrinsically disordered region of eIF4B governs its transition from monomers to oligomers and condensed droplets, providing key insights into how its self-association...

Predicted to be involved in eukaryotic translation initiation factor 4F complex assembly and formation of translation preinitiation complex. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Apr 2022] 生物活性分子 (1)

We have investigated the role of eukaryotic initiation factor 4B (eIF4B) in this process and identify 10-fold more RNA binding sites for eIF4B in tumour cells from patients with diffuse large B-cell lymphoma compared to control B cells and, using individual-nucleotide resolution UV cross-linking and immunoprecipitation, find that eIF4B binds the...

eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells. The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus.

2024年10月28日 · We have investigated the role of eukaryotic initiation factor 4B (eIF4B) in this process and identify 10-fold more RNA binding sites for eIF4B in tumour cells from patients with diffuse large B-cell lymphoma compared to control B cells and, using individual-nucleotide resolution UV cross-linking and immunoprecipitation, find that eIF4B binds ...

1 天前 · 五. eIF4B促进翻译终止. eIF4B促进翻译终止，通过与eIF4A和PABP相互作用，显著提高肽酰-tRNA水解速率，尤其在eRF3a存在下作用更强，可能参与终止的后续阶段或稳定终止复合物结构。 六. eIF4F亚基在翻译终止过程中相互增强活性

Yeast eIF4B (Tif3) consists of an N-terminal domain, followed by a domain with seven repeat regions, an RNA recognition motif and a C-terminal domain (Figure 1C). eIF4B stimulates RNA unwinding by eIF4A without affecting its ATPase activity (13, 26, 31–32).

4 天之前 · Remarkably, eIF4B exhibited a pronounced stimulatory effect on translation termination, resulting in enhancements exceeding an order of magnitude. Notably, the saturating concentrations of eIF4B required for this effect were lower compared with …