EIF4E - Wikipedia
EIF4E with 7MetGTP 4EBP (red) bound to the alpha helices (cyan) of eIF4E. Eukaryotic translation initiation factor 4E , also known as eIF4E , is a protein that in humans is encoded by the EIF4E gene .
真核起始因子4E - 维基百科，自由的百科全书
真核起始因子4E（英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种帽结合蛋白，可以特异性地识别mRNA的5'端的帽子结构，它在真核翻译的起始过程中发挥重要作用。
真核起始因子4E - 百度百科
真核起始因子4E （英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种帽结合蛋白，可以特异性地识别mRNA的5'端的帽子结构，它在真核翻译的起始过程中发挥重要作用。
EIF4E Gene - GeneCards | IF4E Protein | IF4E Antibody
Dec 24, 2024 · EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity).
eIF4E 与 p70 S6 激酶的调控 | Cell Signaling Technology
翻译起始的速率主要取决于三聚物蛋白复合体eIF4F 对 5’ cap 的识别，eIF4F 组分包括：可以结合 5ʹ cap的eIF4E； 前导序列中解旋复合体二级结构所必需的解旋酶eIF4A；eIF4G，一种大型支架蛋白，可将 mRNA 转运至 eIF3 并通过结合多聚 A 结合蛋白 (PABP) 介导 mRNA 环化。
Control of the eIF4E activity: structural insights and …
The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA translation has been clearly assessed in the last decades. eIF4E function is essential for numerous physiological processes, such as protein synthesis, ...
Biological functions and research progress of eIF4E - PMC
Aug 23, 2023 · In this review, we summarize the biological functions and the research progress of eIF4E, the main influencing factors of eIF4E activity, and the recent progress of drugs targeting eIF4E, in the hope of providing new insights for the treatment of multiple malignancies and development of targeted drugs.
The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) …
Nov 22, 2018 · Top left: Decreased phosphorylation of eIF4E promotes depressive and anxiety behaviors by relieving translational repression of pro-inflammatory mRNAs containing repressive 3′ GAIT elements of translation; Bottom left: eIF4E and mTOR are dysregulated in gene expression profiles following MIA, a risk factor for the development ASD; Top right ...
EIF4E eukaryotic translation initiation factor 4E [ (human)]
eIF4E is a critical node in an RNA regulon impacting cell cycle progression. eIF4E coordinately promotes mRNA export of cell cycle genes. eIF4E moves human epithelial cells along the cancer pathway by profoundly altering ribosomal recruitment to cancer-related transcripts
eIF4E的生物学功能及研究进展,Frontiers in Oncology - X-MOL
真核翻译起始因子eIF4E可以特异性结合mRNA 5'端的帽子结构，主要调节翻译起始并优先增强癌变相关mRNA的翻译。 eIF4E的表达与多种恶性肿瘤密切相关。 在肿瘤细胞中，eIF4E活性异常升高，刺激细胞生长、转移和相关蛋白的翻译。