
The ERK-MNK-eIF4F signaling pathway mediates TPDHT
2020年3月1日 · TPDHT induces apoptosis and cell cycle arrest by targeting ERK/MNK/eIF4F. The eIF4E/eIF4G complex plays a central role in gene expression regulation during the initial …
Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E …
The precise mechanism by which eIF4E induces onco-genic transformation remains unclear, but some evidence suggests that the Akt/mTOR and ERK/Mnk1 pathways regulate the activity of …
The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced …
Our results indicate that TPDHT could disrupt the interaction of eIF4E/eIF4G, and the activity of eIF4F plays an important role in TPDHT-induced cell proliferation inhibition and apoptosis. …
Discovery of Potent and Selective MNK Kinase Inhibitors for the ...
2025年3月4日 · MNK activity is regulated by the p38 and Erk MAPK pathways. Phosphorylation of MNK leads to its activation and binding to the eIF4G/eIF4E complex. MNK then …
eIF4F controls ERK MAPK signaling in melanomas with - PNAS
Active MAPK signaling can modulate eIF4F activity via the ERK/MNK axis, promoting eIF4E phosphorylation at Ser209 (19–22). Although we assumed that highly active ERK signaling …
eIF4E-Dependent Translational Control: A Central Mechanism for ...
2018年10月23日 · The mRNA cap-binding protein, eukaryotic translation initiation factor 4E (eIF4E), is involved in the recruitment of the ribosome to the mRNA cap structure, playing a …
Phosphorylation of the mRNA cap-binding protein eIF4E and …
2020年9月1日 · Extracellular signal–regulated kinases (ERKs, including ERK 1 and ERK2) are activated downstream of oncoproteins such as receptor tyrosine kinases, Ras and Raf, and in …
The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) …
Translation initiation, the rate limiting step in protein synthesis, is dependent on the activity of eukaryotic translation Initiation Factor 4E (eIF4E). eIF4E is the cap-binding protein which, in …
MNK-eIF4E signalling is a highly conserved mechanism for …
2019年9月23日 · We propose that MNK-eIF4E signalling is a core, evolutionarily conserved, signalling module that controls nociceptor plasticity. This finding has important implications for …
9HRC: Structure of MNK2 in complex with inhibitor NUCC …
2024年12月17日 · MNK activity is regulated by the p38 and Erk MAPK pathways. Phosphorylation of MNK leads to its activation and binding to the eIF4G/eIF4E complex. MNK then …