2020年3月1日 · TPDHT induces apoptosis and cell cycle arrest by targeting ERK/MNK/eIF4F. The eIF4E/eIF4G complex plays a central role in gene expression regulation during the initial …

The precise mechanism by which eIF4E induces onco-genic transformation remains unclear, but some evidence suggests that the Akt/mTOR and ERK/Mnk1 pathways regulate the activity of …

Our results indicate that TPDHT could disrupt the interaction of eIF4E/eIF4G, and the activity of eIF4F plays an important role in TPDHT-induced cell proliferation inhibition and apoptosis. …

2025年3月4日 · MNK activity is regulated by the p38 and Erk MAPK pathways. Phosphorylation of MNK leads to its activation and binding to the eIF4G/eIF4E complex. MNK then …

Active MAPK signaling can modulate eIF4F activity via the ERK/MNK axis, promoting eIF4E phosphorylation at Ser209 (19–22). Although we assumed that highly active ERK signaling …

2018年10月23日 · The mRNA cap-binding protein, eukaryotic translation initiation factor 4E (eIF4E), is involved in the recruitment of the ribosome to the mRNA cap structure, playing a …

2020年9月1日 · Extracellular signal–regulated kinases (ERKs, including ERK 1 and ERK2) are activated downstream of oncoproteins such as receptor tyrosine kinases, Ras and Raf, and in …

Translation initiation, the rate limiting step in protein synthesis, is dependent on the activity of eukaryotic translation Initiation Factor 4E (eIF4E). eIF4E is the cap-binding protein which, in …

2019年9月23日 · We propose that MNK-eIF4E signalling is a core, evolutionarily conserved, signalling module that controls nociceptor plasticity. This finding has important implications for …

2024年12月17日 · MNK activity is regulated by the p38 and Erk MAPK pathways. Phosphorylation of MNK leads to its activation and binding to the eIF4G/eIF4E complex. MNK then …