2022年12月23日 · In this study, we characterized a dynamic progressive repression of eIF4E activity by hypophosphorylation of 4EBP1 throughout erythropoiesis. However, this fluctuation is not correlated with global protein synthesis activity in vivo.

2020年5月4日 · We found that RALF1 promotes FERONIA-mediated phosphorylation of eIF4E1, a eukaryotic translation initiation factor that plays a crucial role in the control of mRNA translation rate. Phosphorylated eIF4E1 increases mRNA affinity and modulates mRNA translation and, thus, protein synthesis.

2016年8月30日 · Eukaryotic translation initiation factor 4E (eIF4E) plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is required for formation of stress granules (SGs).

2023年12月14日 · Here we report that the germline-specific eIF4E paralog, eIF4E1b, is essential for zebrafish oogenesis. eIF4E1b localizes to P-bodies in zebrafish embryos and binds to mRNAs with reported short or no polyA tails, including histone mRNAs. Loss of eIF4E1b results in reduced histone mRNA levels in early gonads, consistent with a role in mRNA storage.

Our results demonstrate that eIF4E, eIF4G1, eIF4G2, and Pab1p can all be detected to accumulate to some degree in P-bodies under glucose deprivation, and more strikingly in stationary phase for eIF4E, eIF4G2, and Pab1p.

2017年1月6日 · Here, we show that another eIF4E family gene, nCBP, acts as a novel recessive resistance gene in Arabidopsis thaliana toward plant viruses in Alpha- and Betaflexiviridae.

2022年5月14日 · Here, we found that eIF4E2, a hypoxia-activated translation initiation factor, interacted with GSK3β to maintain phosphorylation of p53, thus resisting senescence under hypoxia. RNA-binding protein...

2022年6月29日 · Yeast two-hybrid assays identified that eIF4E1 interacts with an RAC/ROP GTPase activator, RopGEF7, which has been previously reported to be involved in the maintenance of the root apical meristem. The interaction between eIF4E1 and RopGEF7 is confirmed by protein pull-down and bimolecular fluorescent complementation assays in …

Plasmid MSCV eIF4E IRES GFP from Dr. Scott Lowe's lab contains the insert eIF4E and is published in Nature. 2004 Mar 18. 428(6980):332-7. This plasmid is available through Addgene.

Our results show that eIF4E-1 function in early germ cells and the surrounding somatic cells is critical for spermatogenesis. Both eIF4E-1 and eIF4E-3 are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.