真核起始因子4E（英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种帽结合蛋白，可以特异性地识别mRNA的5'端的帽子结构，它在真核翻译的起始过程中发挥重要作用。

Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene. [5][6] Most eukaryotic cellular mRNAs are blocked at their 5' …

Eukaryotic initiation factor 4E (eIF4E) has long been known as the cap-binding protein that participates in recruitment of mRNA to the ribosome. A number of recent advances have not …

2023年8月23日 · In this review, we summarize the biological functions and the research progress of eIF4E, the main influencing factors of eIF4E activity, and the recent progress of drugs …

2010年8月2日 · Here, we show that knock-in mice expressing a nonphosphorylatable form of eIF4E are resistant to tumorigenesis in a prostate cancer model. By using a genome-wide …

In this review, we describe the multifactorial roles of eIF4E in major mRNA-processing events including capping, splicing, cleavage and polyadenylation, nuclear export and translation. We …

2024年8月6日 · We study here how mRNAs are translated in an eIF4E1-independent manner by blocking eIF4E1 using a constitutively active version of eIF4E-binding protein (4E-BP). Via …

2014年6月9日 · We demonstrate that phosphorylation of eIF4E promotes invasion in transformed MEFs, as well as transforming growth factor-beta (TGFβ)-induced EMT in normal epithelial …

2025年2月1日 · Phosphorylated S209 of human/mouse eIF4E (24, 25) and its equivalent S251 in Drosophila eIF4E-1 (26) are key for eIF4E function and cell growth. We analyzed the …

2024年6月6日 · In this issue, Diamond et al. 1 and Kim et al. 2 report that depletion of eIF4E leads to translational upregulation of GCN4, a key player in the integrated stress response, in …