1998年2月20日 · Two human eukaryotic initiation factor 4E (eIF4E) genes were isolated and characterized from placental and chromosome 4-specific genomic libraries.

2024年8月6日 · We study here how mRNAs are translated in an eIF4E1-independent manner by blocking eIF4E1 using a constitutively active version of eIF4E-binding protein (4E-BP). Via ribosome profiling we...

2007年9月4日 · eIF4E expression is reduced in cultured human and murine cells. (A) eIF4E expression was assessed by quantitative RT-PCR. Representative data are shown for human cervical carcinoma cells (HeLa), human non–small cell lung cancer cells (A549), and murine endothelial cells (b.END cells) 24 hours after transfection.

2006年11月6日 · This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical node in an RNA regulon that impacts nearly every stage of cell cycle progression. Specifically, eIF4E coordinately promotes the messenger RNA (mRNA) export of several genes involved in the cell cycle.

2025年2月7日 · Our investigation revealed that PRSS23 interacts with eIF4E via its trypsin domain, while eIF4E binds to PRSS23 through the amino acid residue S209, as confirmed by co-IP and immunofluorescence...

真核起始因子4E（英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种帽结合蛋白，可以特异性地识别mRNA的5'端的帽子结构，它在真核翻译的起始过程中发挥重要作用。

Here, we demonstrate a method for the rapid selection of looped DNA aptamers against eIF4e by combining negative selection and purification in a single step, followed by characterization with high throughput sequencing. The resulting aptamers show functional binding to eIF4e and inhibit translation initiation in biochemical assays.

2014年6月9日 · We demonstrate that phosphorylation of eIF4E promotes invasion in transformed MEFs, as well as transforming growth factor-beta (TGFβ)-induced EMT in normal epithelial cells. We identify mRNAs...

The m7G cap binding protein eukaryotic initiation factor 4E (eIF4E) is a rate-limiting determinant of protein synthesis. Elevated eIF4E levels, commonly associated with neoplasia, promote oncogenesis, and phosphorylation of eIF4E at Ser209 is ...

Real-time PCR primer assay designed for SYBR ® Green gene expression analysis. Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene expression analysis.