eIF4E S209 phosphorylation licenses myc- and stress-driven
2020年11月2日 · To better understand a role of eIF4E S209 in oncogenic translation, we generated EIF4ES209A/+ heterozygous knockin (4EKI) HCT 116 human colorectal cancer …
eIF4E S209 phosphorylation licenses myc- and stress-driven
2020年11月2日 · Using EIF4E S209A/+ knockin (4EKI) human colon cancer cells and mice, human CRC organoids and adenoma samples, we uncovered a key role of p-4E in Myc and …
eIF4E phosphorylation promotes tumorigenesis and is associated …
2010年8月2日 · Ser209 Is the Only Phosphorylation Site in eIF4E. To address the role of eIF4E phosphorylation in tumorigenesis, a knock-in (KI) mouse in which serine 209 was replaced by …
Using EIF4E S209A/+ knockin (4EKI) human colon cancer cells and mice, human CRC organoids and adenoma sam-ples, we uncovered a key role of p-4E in Myc and ATF4 translation, which …
eIF4E S209 磷酸化许可 Myc 和压力驱动的肿瘤发生,eLife - X-MOL
2020年11月2日 · 为了更好地了解 eIF4E S209 在致癌翻译中的作用，我们生成了 EIF4ES209A/+ 杂合敲入 (4EKI) HCT 116 人结直肠癌 (CRC) 细胞。 4EKI 对总 eIF4E 水平、帽结合或全局翻 …
The Androgen Receptor is a negative regulator of eIF4E …
Rapamycin and its analogs increased eIF4E(S209) phosphorylation at S209, despite no direct activation site for rapamycin on this protein (36–38). We now show that the effects of both …
解释eIF4E磷酸化对mRNA帽识别的机制作用。,Protein Science - X …
eIF4E磷酸化的结果出现的一个关键特征是磷酸化的S209（pS209）与eIF4E帽结合界面中特定的赖氨酸残基对（K159和K162）之间的盐桥网络。 这种相互作用使蛋白质的动态C端区域稳定 …
The Androgen Receptor Is a Negative Regulator of eIF4E
2017年11月16日 · We confirmed using a human-derived tumor xenograft mouse model that bicalutamide pre-treatment is associated with an increase in eIF4E (S209) phosphorylation. …
Deciphering the mechanistic effects of eIF4E phosphorylation
The mRNA cap-binding oncoprotein "eIF4E" is phosphorylated at residue S209 by Mnk kinases, and is closely associated with tumor development and progression. Despite being well …
Dryad | Data -- eIF4E S209 phosphorylation licenses myc- and …
2021年2月2日 · Mutational activation of Wnt/Myc and RAS signaling promotes colorectal cancer (CRC) development and deregulates translation. Phosphorylation of the cap binding protein …