Structural studies of the eIF4E-VPg complex reveal a direct ... - PubMed
2019年11月26日 · The potyvirus-derived viral genome-linked protein (VPg) is covalently bound to the 5' end of viral genomic RNA (gRNA) and associates with host eIF4E for successful …
Structural studies of the eIF4E–VPg complex reveal a direct ... - PNAS
2019年11月12日 · Here, we unexpectedly found that a small viral protein, viral genome-linked protein (VPg), directly binds the cap-binding site of eIF4E, indicating that eIF4E can …
Selective Interaction of Sugarcane eIF4E with VPgs from …
2021年3月22日 · Eukaryotic translation initiation factor 4E (eIF4E) plays a key role in the infection of potyviruses in susceptible plants by interacting with viral genome-linked protein (VPg). …
The Naturally Occurring Amino Acid Substitution in the VPg …
2024年11月25日 · PVY isolates carrying equivalent amino acid mutations of K105E or V108I in VPg can re-hijack eIF(iso)4E and infect eIF4E-knockdown tobacco plants (Takakura et al. …
VPg directly bound the cap-binding site of eIF4E and competed for m7G cap analog binding. In human cells, VPg inhibited eIF4E-dependent RNA export, translation, and oncogenic …
VPg of Potato Virus Y and Potato Cap-Binding eIF4E Factors
Translation of viral RNA starts with the interaction between the plant cap-binding translation initiation factors eIF4E and viral genome-linked protein (VPg) covalently attached to the viral …
(PDF) Structural studies of the eIF4E–VPg complex reveal a direct ...
2019年11月11日 · To dissect these possibilities, we resolved the structure of VPg, revealing a previously unknown 3-dimensional (3D) fold, and characterized the VPg–eIF4E complex using …
Structural studies of the eIF4E–VPg complex reveal a direct …
We demonstrated that VPg binds the cap-binding site of eIF4E and forms trimeric complexes with eIF4E and eIF4G; furthermore, we demonstrated that VPg–RNA conjugates directly bind …
甘蔗 eIF4E 与甘蔗花叶病原体 VPg 的选择性相互作用,Viruses - X …
2021年3月22日 · 本研究揭示了甘蔗花叶病菌侵染甘蔗植物的分子机制，有利于甘蔗育种抗甘蔗花叶病。 Eukaryotic translation initiation factor 4E (eIF4E) plays a key role in the infection of …
Natural variation and functional analyses provide evidence for …
With the dual objective of testing the impact of the distinct combinations of amino acid changes identified in eIF4E proteins on interaction with the viral VPg, and obtaining insights into …