
EIF4E - Wikipedia
Many cellular mRNAs require eIF4E in order to be translated into protein. The eIF4E polypeptide is considered by some to be the rate-limiting component of the eukaryotic translation …
真核起始因子4E - 维基百科,自由的百科全书
真核起始因子4E (英文:eukaryotic initiation factor 4E,简称“eIF4E”)是一种 帽结合蛋白,可以特异性地识别 mRNA 的 5'端 的 帽子结构,它在 真核翻译 的起始过程中发挥重要作用。 …
eIF4E orchestrates mRNA processing, RNA export and translation …
In this review, we describe the multifactorial roles of eIF4E in major mRNA-processing events including capping, splicing, cleavage and polyadenylation, nuclear export and translation. We …
eIF4E, the mRNA cap-binding protein: from basic discovery to ...
A prime target of translational control is the initiation factor eIF4E, which recognizes the m7GpppN cap structure present at the 5' end of all nuclear transcribed eukaryotic mRNAs. In this article I …
Control of the eIF4E activity: structural insights and …
The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA translation has been clearly assessed in the last decades. eIF4E function is essential for …
eIF4E-independent translation is largely eIF3d-dependent
2024年8月6日 · We study here how mRNAs are translated in an eIF4E1-independent manner by blocking eIF4E1 using a constitutively active version of eIF4E-binding protein (4E-BP). Via …
Full article: eIF4E orchestrates mRNA processing, RNA export and ...
In this review, we describe the multifactorial roles of eIF4E in major mRNA-processing events including capping, splicing, cleavage and polyadenylation, nuclear export and translation. We …
The mRNA cap-binding protein eIF4E in post-transcriptional …
2004年5月25日 · Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects...
A biochemical framework for eIF4E-dependent mRNA export and …
2016年11月29日 · The eukaryotic translation initiation factor eIF4E plays a major role in post-transcriptional regulation of gene expression (Carroll and Borden 2013). eIF4E is localized in …
eIF4E-binding protein regulation of mRNAs with differential 5′ …
Abstract. Control of translation in eukaryotes is complex, depending on the binding of various factors to mRNAs. Available data for subsets of mRNAs that are translationally up- and down …