Many cellular mRNAs require eIF4E in order to be translated into protein. The eIF4E polypeptide is considered by some to be the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis.

真核起始因子4E （英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种 帽结合蛋白，可以特异性地识别 mRNA 的 5'端 的 帽子结构，它在 真核翻译 的起始过程中发挥重要作用。 eIF4E可以与 eIF4A 和 eIF4G 共同组成 eIF4F 复合物 参与真核翻译起始。 因此，通过与mRNA的5'端的帽子结构结合，eIF4E就可以将eIF4A带到mRNA的5'端，让eIF4A发挥 解旋酶 活性来打开mRNA的5'端的二级结构。 [1] 在 真核生物 中，eIF4E有许多 异构体；在不同物种间，其数量也有差异 …

In this review, we describe the multifactorial roles of eIF4E in major mRNA-processing events including capping, splicing, cleavage and polyadenylation, nuclear export and translation. We discuss the evidence that eIF4E acts at two levels to generate widescale changes to processing, export and ultimately the protein produced.

A prime target of translational control is the initiation factor eIF4E, which recognizes the m7GpppN cap structure present at the 5' end of all nuclear transcribed eukaryotic mRNAs. In this article I describe the discovery of eIF4E, its mechanism of action in translation initiation, and its role in the control of cancer and innate immunity.

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA translation has been clearly assessed in the last decades. eIF4E function is essential for numerous physiological processes, such as protein synthesis, cellular growth and differentiation; dysregulation of its activity has been linked to ageing, cancer ...

2024年8月6日 · We study here how mRNAs are translated in an eIF4E1-independent manner by blocking eIF4E1 using a constitutively active version of eIF4E-binding protein (4E-BP). Via ribosome profiling we...

In this review, we describe the multifactorial roles of eIF4E in major mRNA-processing events including capping, splicing, cleavage and polyadenylation, nuclear export and translation. We discuss the evidence that eIF4E acts at two levels to generate widescale changes to processing, export and ultimately the protein produced.

2004年5月25日 · Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects...

2016年11月29日 · The eukaryotic translation initiation factor eIF4E plays a major role in post-transcriptional regulation of gene expression (Carroll and Borden 2013). eIF4E is localized in both the nucleus and cytoplasm where it acts in the mRNA export and translation of a specific subset of mRNAs, respectively (Carroll and Borden 2013).

Abstract. Control of translation in eukaryotes is complex, depending on the binding of various factors to mRNAs. Available data for subsets of mRNAs that are translationally up- and down-regulated in yeast eIF4E-binding protein (4E-BP) deletion mutants are coupled with reported mRNA secondary structure measurements to investigate whether 5′-UTR secondary structure varies between the subsets.