Many cellular mRNAs require eIF4E in order to be translated into protein. The eIF4E polypeptide is considered by some to be the rate-limiting component of the eukaryotic translation …

真核起始因子4E （英文：eukaryotic initiation factor 4E，简称“eIF4E”）是一种 帽结合蛋白，可以特异性地识别 mRNA 的 5'端 的 帽子结构，它在 真核翻译 的起始过程中发挥重要作用。 …

In this review, we describe the multifactorial roles of eIF4E in major mRNA-processing events including capping, splicing, cleavage and polyadenylation, nuclear export and translation. We …

A prime target of translational control is the initiation factor eIF4E, which recognizes the m7GpppN cap structure present at the 5' end of all nuclear transcribed eukaryotic mRNAs. In this article I …

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA translation has been clearly assessed in the last decades. eIF4E function is essential for …

2024年8月6日 · We study here how mRNAs are translated in an eIF4E1-independent manner by blocking eIF4E1 using a constitutively active version of eIF4E-binding protein (4E-BP). Via …

In this review, we describe the multifactorial roles of eIF4E in major mRNA-processing events including capping, splicing, cleavage and polyadenylation, nuclear export and translation. We …

2004年5月25日 · Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects...

2016年11月29日 · The eukaryotic translation initiation factor eIF4E plays a major role in post-transcriptional regulation of gene expression (Carroll and Borden 2013). eIF4E is localized in …

Abstract. Control of translation in eukaryotes is complex, depending on the binding of various factors to mRNAs. Available data for subsets of mRNAs that are translationally up- and down …