eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E (cap-binding) and EIF4G1/EIF4G3 (PubMed: 7651417, PubMed: 7935836, PubMed: 9372926).

eIF4G（eukaryotic translation initiation factor 4G，真核起始因子4G）是一种在真核翻译起始进程中发挥重要作用的蛋白质。 它主要是在轉譯起始早期协同不同起始因子间的作用和增强它们的活性（包括 eIF4E 的帽结合活性， eIF4A 的 RNA 解旋酶 活性， PABP 的poly-A结合活性 ...

2014年5月16日 · In this study, the role of eIFiso4G in plant growth was investigated using null mutants for the eIF4G isoforms in Arabidopsis. eIFiso4G loss of function mutants exhibited smaller cell, leaf, plant size, and biomass accumulation that correlated with its reduced photosynthetic activity, phenotypes not observed with the eIF4G loss of function mutant.

eIF4G stands for eukaryotic initiation factor 4 gamma (typically gamma is now replaced by G in the literature). It was initially isolated by fractionation, found present in fraction 4 gamma, and was involved in eukaryotic translation initiation.

2010年8月8日 · Leaf samples were ground in liquid nitrogen and extracted with 90% (v/v) acetone. The absorbance at 664 and 647 nm was determined and used to calculate chlorophyll a and b content by the equations: Chl a = 11.93A 664 − 1.93A 647 and Chl b = 20.36A 647 − 5.50A 664, respectively. Each experiment was repeated 2–3 times and representative ...

2024年5月2日 · In this issue of Molecular Cell, 1 Desroches Altamirano et al. reported a scaffold protein in protein translation initiation, called eIF4G, as a thermosensor during the heat shock response in yeast. The eIF4F complex, comprising eIF4A/E/G, is a crucial checkpoint for protein translation initiation (Figure 1).

View eIF4G1 Antibody [Alexa Fluor® 647] (NB100-268AF647) validated in 2 species & 2 applications from Novus Biologicals.

eif4g抗体（a-10）是一种igg2bκ小鼠单克隆eif4g抗体（也称为eif4g1抗体），可通过wb、ip、if、ihc（p）和elisa检测小鼠、大鼠和人源的eif4g蛋白。 eIF4G抗体（A-10）可作为非偶联抗eIF4G抗体形式，以及多种偶联形式的抗eIF4G抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor ...

Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this …

Several data indicate that the inhibition of eIF4E in tumor cell lines and xenograft models impairs tumor growth and induces apoptosis; eIF4E, therefore, can be considered a valuable target for cancer therapy. Targeting the cap-binding pocket of eIF4E should represent a way to inhibit all the eIF4E cellular functions.