真核翻译起始因子5A（eukaryotic translation initiation factor 5A, eIF5A）是维持细胞活性必不可少的翻译因子，在进化上高度保守。eIF5A是真核细胞中唯一含有羟腐胺赖氨酸（hypusine）的蛋白质，该翻译后修饰对eIF5A的活性至关重要。

2022年12月17日 · Here we show that the function of the elongation factor, eIF5a, is regulated dynamically in naïve CD8 + T cells upon activation by post-translational modification, whereupon it facilitates...

Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. [ 5 ] It is the only known protein to contain the unusual amino acid hypusine [ N ε -(4-amino-2-hydroxybutyl)-lysine], which is synthesized on eIF5A at a specific lysine residue from the polyamine spermidine by two catalytic steps.

eIF5A结合在E位点（exit site，出口位），与肽基tRNA的受体臂相互作用，通过诱导底物的有利定位来促进肽键形成。 eIF5A含有一个羟丁胺修饰的赖氨酸（hypusine），我们在讲多胺合成时提到过。

eIF3a是eIF3的最大亚基，它是翻译启动所有步骤的关键参与者。 上海懿贝瑞生物发现，eIF3a的主要功能表现在： 1）翻译启动。 作为翻译起始因子，eIF3a…

2022年6月22日 · Single-molecule fluorescence revealed when the universally conserved eukaryotic initiation factors eIF1A and eIF5B associate with and depart from initiation complexes. Guided by single-molecule...

真核翻译起始因子5A（eukaryotic translation initiation factor 5A, eIF5A）是维持细胞活性必不可少的翻译因子,在进化上高度保守。eIF5A是真核细胞中唯一含有羟腐胺赖氨酸（hypusine）的蛋白质,该翻译后修饰对eIF5A的活性至关重要。

2019年9月5日 · eIF3 is a large multiprotein complex serving as an essential scaffold promoting binding of other eIFs to the 40S subunit, where it coordinates their actions during translation initiation. Perhaps due to a high degree of flexibility of multiple eIF3 subunits, a high-resolution structure of free eIF3 …

2024年12月24日 · EIF5A (Eukaryotic Translation Initiation Factor 5A) is a Protein Coding gene. Diseases associated with EIF5A include Faundes-Banka Syndrome and Non-Specific Syndromic Intellectual Disability. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation.

2014年8月28日 · 学的方法，我们成功解析了eIF3中k亚基的全长结构以及eIF5的c端结构 域的结构；并尝试用电子显微镜来研究eIF3复合物的整体结构。 对elF3和