2024年5月28日 · Our new method, ePRINT, maps RBP-RNA interaction networks on a global scale without purifying individual RBPs. ePRINT uses exoribonuclease XRN1 to precisely map the 5′ end of the RBP binding site and uncovers direct and indirect targets of an RBP of interest.

2024年5月8日 · We have developed a new method (ePRINT) to map RBP-RNA interaction networks on a global scale without purifying individual RBPs. By deploying the exoribonuclease XRN1, ePRINT allows precise mapping of the 5’ end of the RBP binding site and uncovers direct and indirect targets of an RBP of interest.

最新研究发现了一种名为eprint的新方法，可以在全局范围内绘制rbp-rna相互作用网络，而无需纯化单个rbps。 ePRINT利用外切核酸酶XRN1来精确绘制RBP结合位点的5'端，并揭示了感兴趣的RBP的直接和间接靶标。

2024年7月16日 · Our new method, ePRINT, maps RBP-RNA interaction networks on a global scale without purifying individual RBPs. ePRINT uses exoribonuclease XRN1 to precisely map the 5′ end of the RBP binding site and uncovers direct and indirect targets of an RBP of interest.

Our new method, ePRINT, maps RBP-RNA interaction networks on a global scale without purifying individual RBPs. ePRINT uses exoribonuclease XRN1 to precisely map the 5′ end of the RBP binding site and uncovers direct and indirect targets of an RBP of interest.

RNA based cellular processes that expands genomic diversity, and it is essential in the development and function of complex organisms. Not surprisingly, misfunction of the different RNA regulation steps has been associated with a range of pathologies, including different cancers, neurodevelopmental and neurodegenerative diseases, immuno-pathologies

Our new method, ePRINT, maps RBP-RNA interaction networks on a global scale without purifying individual RBPs. ePRINT uses exoribonuclease XRN1 to precisely map the 5′ end of the RBP binding site and uncovers direct and indirect targets of an RBP of interest.

我们的新方法 ePRINT 在全球范围内绘制 RBP-RNA 相互作用网络，而无需纯化单个 RBP。 ePRINT 使用核糖核酸外切酶 XRN1 精确定位 RBP 结合位点的 5' 端，并发现感兴趣的 RBP 的直接和间接靶标。 重要的是，ePRINT 还可以发现在细胞命运转变之间差异激活的 RBP，包括神经祖细胞分化为神经元。 RNA 结合蛋白 (RBP) 通过物理结合 RNA 分子来调节 RNA 加工的关键方面，包括选择性剪接、mRNA 降解和定位。 目前绘制这些相互作用的方法（例如 CLIP）依赖于 …

2024年3月4日 · We have developed a new method (ePRINT) to map RBP-RNA interaction networks on a global scale in an RBP agnostic manner. Our method allows precise mapping of the 5’ end of the RBP binding site and uncovers RBPs …

2023年5月16日 · We have developed a new method (ePRINT) to map RBP-RNA interaction networks on a global scale without purifying individual RBPs. ePRINT allows precise mapping of the 5’ end of the RBP binding site, and can uncover …