The Dyno eCap 1 capsid achieves highly efficient transduction of of bipolar cells, enabling optogenetic therapeutic interventions in advanced retinal disease progression. Cell-specific co …

2023年10月25日 · The Dyno eCap 1 vector consistently transduces cell types broadly across retinal layers, including rod cel, bipolar cells and retinal ganglion cells. The Dyno eCap 1 …

2023年10月25日 · WATERTOWN, Mass.--(BUSINESS WIRE)--Dyno Therapeutics, Inc., a techbio company pioneering applications of artificial intelligence to engineer AAV capsids that can …

2023年10月30日 · Per Dyno, the Dyno eCap 1 capsid is essentially designed to provide significantly improved delivery (vs other externally engineered capsids) to the eye, including …

Here we characterize the Dyno eCap 1 capsid, a novel capsid designed with generative AI leveraging in vivo data from multiplexed measurements of capsid libraries.

The Dyno eCap 1 vector consistently transduces cell types broadly across retinal layers, including rod cel, bipolar cells and retinal ganglion cells. The Dyno eCap 1 vector was validated in …

2023年10月11日 · Dyno’s scientific symposium will showcase in vivo NHP data on field-leading capsids across the eye and CNS. Dyno’s AI-designed capsids significantly advance gene …

Dyno’s AI-powered design platform identified 7 sequence edits, to transform AAV9 into the bCap 1 capsid and improve delivery. The Dyno bCap 1 capsid reaches 5-20% of neurons and …

Dyno Therapeutics Launches Dyno eCap 1™ Vector, a Field-Leading AAV Capsid for Eye Gene Therapies

2023年10月26日 · The Dyno eCap 1 vector consistently transduces cell types broadly across retinal layers, including rod cel, bipolar cells and retinal ganglion cells. The Dyno eCap 1 …