For example, HLH-mediated oligomerization between WT ETV6 and ETV6:JAK2 may reduce the availability of the endogenous ETV6 HLH motif, which normally maintains long-term …

2014年3月1日 · The HLH domain of ETV6 is fused to the protein kinase domain(s), the ATP nucleotide binding, and the loop structure of JAK2; according to the different possible …

2017年2月9日 · ETV6-JAK2 and BCR-JAK2 may be considered variants of PCM1-JAK2; the small number of ETV6-JAK2 and BCR-JAK2 cases have presented as myeloid neoplasms …

Taken together, the zebrafish modeling of ETV6-JAK2 leukemia by Onnebo and colleagues described in this issue of the Journal provides evidence for the in vivo potential of ETV6-JAK2 …

2012年8月1日 · The ETV6-JAK2 fusion gene generated by the t(9;12)(p24;p13) has been described in only three patients with different types of malignant hemopathies. Peeters et al.

Background: Chromosomal translocations resulting in alternative fusions of the human TEL (ETV6) and JAK2 genes have been observed in cases of acute lymphoblastic leukemia and …

The JAK2 p.G993A mutation confers resistance in vitro, even to high dose JAK2 inhibitors such as ruxolitinib. We postulated that direct inhibition of STAT3 and STAT5, downstream from …

Both changes involved the ETV6 gene at 12p13 and the JAK2 gene at 9p24. In each case different fusion mRNAs were found, with only 1 resulting in a chimeric protein consisting of the …

1997年10月1日 · We here report the identification of JAK2 as a fusion partner of ETV6 in t (9; 12) (p24; p13) found in leukemic cells of a child with early B-precursor ALL and in t (9; 15; 12) …

Both changes involved the ETV6 gene at 12p13 and the JAK2 gene at 9p24. In each case different fusion mRNAs were found, with only 1 resulting in a chimeric protein consisting of the …