
JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular …
For example, HLH-mediated oligomerization between WT ETV6 and ETV6:JAK2 may reduce the availability of the endogenous ETV6 HLH motif, which normally maintains long-term …
t(9;12)(p24;p13) ETV6/JAK2 - atlasgeneticsoncology.org
2014年3月1日 · The HLH domain of ETV6 is fused to the protein kinase domain(s), the ATP nucleotide binding, and the loop structure of JAK2; according to the different possible …
Myeloid neoplasms with eosinophilia | Blood | American Society of ...
2017年2月9日 · ETV6-JAK2 and BCR-JAK2 may be considered variants of PCM1-JAK2; the small number of ETV6-JAK2 and BCR-JAK2 cases have presented as myeloid neoplasms …
Modeling ETV6-JAK2-induced leukemia: insights from the zebrafish
Taken together, the zebrafish modeling of ETV6-JAK2 leukemia by Onnebo and colleagues described in this issue of the Journal provides evidence for the in vivo potential of ETV6-JAK2 …
ETV6 fusion genes in hematological malignancies: A review
2012年8月1日 · The ETV6-JAK2 fusion gene generated by the t(9;12)(p24;p13) has been described in only three patients with different types of malignant hemopathies. Peeters et al.
Alternative TEL-JAK2 fusions associated with T-cell acute
Background: Chromosomal translocations resulting in alternative fusions of the human TEL (ETV6) and JAK2 genes have been observed in cases of acute lymphoblastic leukemia and …
Direct STAT3 and STAT5 Inhibition Overcomes Treatment
The JAK2 p.G993A mutation confers resistance in vitro, even to high dose JAK2 inhibitors such as ruxolitinib. We postulated that direct inhibition of STAT3 and STAT5, downstream from …
Entry - *147796 - JANUS KINASE 2; JAK2 - OMIM
Both changes involved the ETV6 gene at 12p13 and the JAK2 gene at 9p24. In each case different fusion mRNAs were found, with only 1 resulting in a chimeric protein consisting of the …
Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor ...
1997年10月1日 · We here report the identification of JAK2 as a fusion partner of ETV6 in t (9; 12) (p24; p13) found in leukemic cells of a child with early B-precursor ALL and in t (9; 15; 12) …
Entry - *600618 - ETS VARIANT TRANSCRIPTION FACTOR 6; ETV6
Both changes involved the ETV6 gene at 12p13 and the JAK2 gene at 9p24. In each case different fusion mRNAs were found, with only 1 resulting in a chimeric protein consisting of the …