Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]

2024年12月25日 · FTO (FTO Alpha-Ketoglutarate Dependent Dioxygenase) is a Protein Coding gene. Diseases associated with FTO include Growth Retardation, Developmental Delay, And Facial Dysmorphism and Lethal Polymalformative Syndrome, Boissel Type.

2021年7月20日 · What is the FTO Gene? The FTO gene was identified in 2007 in a genome-wide association study that looked at over 35,000 people to determine genes involved in obesity. Variants in the gene are strongly linked to the likelihood of having a higher BMI. But…

The fat mass and obesity-associated (FTO) gene was the first obesity-susceptibility gene identified through a genome-wide association study (GWAS). A growing number of studies have suggested that genetic variants of FTO are strongly associated with ...

The fat mass and obesity-associated (FTO) gene, identified by genome-wide association studies (GWAS), was first reported to be positively associated with obesity in humans. Mice with more copies of the FTO gene were observed to be obese, while loss of the gene in mice was found to protect from obesity.

2020年11月16日 · In this review, we comprehensively discuss the correlation between obesity and cancer by measuring FTO gene polymorphism, as well as the molecular mechanism involved in these diseases, emphasizing FTO as the common genetic basis of obesity and cancer.

2023年12月20日 · The Fto gene, also known as fat mass and obesity-associated gene, is a gene that plays a crucial role in regulating body weight and metabolism. However, recent studies have shown that mutations in the Fto gene can also have a significant impact on brain development.