Here we show that gamma‐glutamyltransferase 1 (GGT1)‐SNP rs5751901 is an eQTL in pancreatic cells associated with PEP and a positive regulator of the IL‐6 amplifier. More PEP …
(GGT1, EC 2.3.2.2) activity in blood are widely used in a clinical setting to measure tissue damage. The well-charac-terized GGT1 is an extracellular enzyme that is anchored to the …
GGT1 catalyzes the degradation of extracellular GSH, thus favouring the recovery of constituent amino acids and contributing to the modulation of cysteine homeostasis and redox status of cells.
(PDF) Human Gamma-Glutamyl Transpeptidase 1: Structures
2015年5月26日 · Gamma-glutamyl transpeptidase 1 (GGT1) is a cell surface, N-terminal nucleophile hydrolase that cleaves glutathione and other gamma-glutamyl compounds. GGT1...
γ-glutamyl transpeptidase (GGT1, aka γ-glutamyl transferase) is a cell surface enzyme that cleaves extra-cellular glutathione (GSH), GSH S-conjugates, and other γ-glutamyl compounds …
In this study, we report four new crystal structures of human GGT1 (hGGT1) that show conformational changes within the active site as the enzyme progresses from the free enzyme …
Abstract: Ggt1dwg/dwg mice are spontaneous mutant mice with a nucleotide deletion in the Ggt1 gene. They are characterized by dwarfism, cataract, and coat color abnormality. These …
(PDF) GGT1 Suppresses the Development of Ferroptosis and
2023年11月21日 · The TEM and immunofluorescent results indicated that mitochondria impairment and autophagosome accumulation in OGD/R-treated cells was improved after …
(PDF) GGT1 in Glioblastoma: Ferroptosis Resistance - Academia.edu
Experimental Design: In this pilot study, we (a) genotyped 112 newly diagnosed glioblastoma patients ascertained through a population-based study (group 1) with the ParAllele assay …
From the perspective of amino acid sequences, genes showing substantial similarity (GGT5, GGT6, and GGT7) to GGT1 have been identified. The aim of this study was to investigate the …