2024年12月25日 · MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP4K4 include Anus, Imperforate and Renal Dysplasia. Among its related pathways are Cellular responses to stimuli and Cellular Senescence.

Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) – also known as hepatocyte progenitor kinase-like/germinal center kinase-like kinase (HGK) and Nck-interacting kinase (NIK) – is an enzyme, specifically a serine/threonine (S/T) kinase encoded by …

2016年1月1日 · Loss of HGK in T cells results in spontaneous systemic inflammation and type 2 diabetes in mice. HGK is also involved in cancer cell migration. To date, the phenotypes of knockout mice for GCK, KHS, and MINK have not been reported; the roles of these three MAP4Ks in immune cell signaling are discussed in this review.

2016年10月28日 · MAP4K4, also known as HGK (hematopoietic progenitor kinase/germinal center kinase-like kinase) or NIK (Nck interacting kinase, the mouse ortholog) is a serine/threonine (S/T) kinase that belongs to the mammalian family of Ste20 protein kinases due to their shared homology to the budding yeast kinase Ste20p [1].

2024年8月1日 · MAP4K4, also known as a HGK (human ortholog) and Nck-interacting kinase (NIK; mouse ortholog) (Delpire, 2009), is a serine/threonine protein kinase that serves as an upstream regulator of MAPK signaling (Singh et al., 2023). The MAP4K4 gene is located on chromosome 2q11.2 in humans and comprises 33 exons (Wright et al., 2003).

We have identified a novel HGK (HPK-like/GCK-like kinase) gene product from a human SNB19 glioblastoma cell line library. The cDNA isolated was 3,798 bp long, encoding a protein of 1,239 amino acids.

2021年6月10日 · Here, we have identified MAP4K4 as a relevant gene for metastasis in PCa. Our work shows that genetic deletion of MAP4K4 or pharmacological inhibition of its encoded kinase, HGK, inhibits...

HGK promotes metastatic dissemination in prostate cancer. MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity. Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells.

HGK (hepatocyte progenitor kinase-like/germinal center kinase-like kinase) is a member of the human STE20/mitogen-activated protein kinase kinase kinase kinase family of serine/threonine kinases and is the ortholog of mouse NIK (Nck-interacting kinase). We have cloned a novel splice variant of HGK f …

2014年5月26日 · HGK在卵巢癌、肝癌、肺癌、胰腺癌及前列腺癌等多种肿瘤中高表达，有可能成为肿瘤治疗的新作用靶点或预防某些肿瘤的发生。 本文就HGK在肿瘤中的研究进展及可能的作用机制进行综述。

MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian Ste20-like family of serine/threonine kinases. MAP4Ks including MAP4K1/HPK1, MAP4K2/GCK, MAP4K3/GLK, MAP4K4/HGK, MAP4K5/KHS, and MAP4K6/MINK have been reported to induce JNK activation through activating the MAP3K-MAP2K cascade.

The gene view histogram is a graphical view of mutations across MAP4K4. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left.

Using degenerate polymerase chain reaction, we have isolated a human cDNA encoding a protein kinase homologous to STE20. This protein kinase, designated HPK/GCK-like kinase (HGK), has nucleotide sequences that encode an open reading frame …

AIM: To investigate the effects of RNA interference targeting hepatocyte progenitor kinase-like kinase (HGK) in the invasion and adhesion of hepatocellular carcinoma (HCC) cell line HepG2. METHODS: Three paired insert DNA fragments specific to HGK ...

4 天之前 · Here we developed a random forest-based machine-learning pipeline, NeuRGI (Neutrophil Regulatory Gene Identifier), which utilized Positive-Unlabeled Learning (PU-learning) and neural network-based in silico gene knockout to identify neutrophil regulators.

2015年12月21日 · Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4; also known as Nck-interacting kinase (NIK) and hepatocyte progenitor kinase-like/germinal centre kinase-like kinase (HGK)) belongs...

GLK过度表达T细胞的百分比与疾病活动性相关。 另外，HGK磷酸化并诱导TRAF2蛋白降解，从而导致静止T细胞中IL-6产生的负调控。 T细胞中HGK的丢失会导致小鼠自发性全身炎症和2型糖尿病。 HGK也参与癌细胞的迁移。

1. Humans have three kallikrein genes: hGK-1, hRKALL (kinin-generating) and a gene encoding prostate specific antigen (PSA). 2. Using a gene-specific oligonucleotide, expression of hGK-1 was demonstrated in human prostate, but not in 10 other tissues examined. 3. The similarity in tissue specificity …

HGK Antibody detects endogenous levels of total HGK protein. Human, Mouse, Rat, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human HGK. Antibodies are purified by protein A and peptide affinity chromatography.

特异性： HGK Monoclonal Antibody detects endogenous levels of HGK protein. 组成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. 稀释： WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.