2013年6月1日 · Well-orchestrated epithelial–mesenchymal interactions are crucial for hair follicle (HF) morphogenesis. In this study, ectodermal precursor cells (EPCs) with the capacity to cross talk with hair-inductive dermal cells were generated from human induced pluripotent stem cells (hiPSCs) and assessed for HF-forming ability in vivo.

2025年3月13日 · B Pathway enrichment analysis of DEGs in NNMT + SFRP1 + PC, basal stem cell, and mature EpC in the EV-A71-infected hiPSC-SOs between 8 dpi and 0 dpi. The upregulated and downregulated DEGs are ...

2020年6月30日 · Transplantation of endothelial progenitor cells (EPCs) has high therapeutic potential for ischemia-related ailments like heart attacks and claudication. Due to limited EPC sources, direct reprogramming is a fast-developing way to convert human-induced pluripotent stem cells (hiPSCs) into EPCs fit for transplantation.

Well-orchestrated epithelial–mesenchymal interactions are crucial for hair follicle (HF) morphogenesis. In this study, ectodermal precursor cells (EPCs) with the capacity to cross talk with hair-inductive dermal cells were generated from human induced pluripotent stem cells (hiPSCs) and assessed for HF-forming ability in vivo.

Well-orchestrated epithelial-mesenchymal interactions are crucial for hair follicle (HF) morphogenesis. In this study, ectodermal precursor cells (EPCs) with the capacity to cross talk with hair-inductive dermal cells were generated from human induced pluripotent stem cells (hiPSCs) and assessed for HF-forming ability in vivo.

人类多能干细胞（hPSCs）的发现，包括 人类胚胎干细胞 (hESCs)和 人类诱导多能干细胞 (iPSCs)，使干细胞研究和基于细胞的治疗发生了革命性的变化。 hESCs于1998年首次从囊胚期胚胎中分离出来，随后进行了突破性的重新编程研究，仅使用四个遗传因素就将体细胞转化为iPSCs。 目前已经开发来在体外长期保持这些细胞并启动它们向多种细胞类型分化的方法，这开启了再生医学的新纪元，特别是用于替代丢失或受损组织的细胞治疗。 本文就hPSCs做一个简 …

2024年3月13日 · 我们也已在这一领域进行了布局，目前，我们已陆续成功制备存储30个超级供体iPSC细胞株，估算可覆盖约50%全国人口，即7亿中国人群，并建立了临床 ...

2023年9月15日 · 最近，中国研究人员在无异种培养条件下也开发了临床级的hESC-RPE细胞，用于治疗湿性年龄相关性变性患者。 由于hESC的伦理问题和免疫排斥反应问题凸显，使得hiPSC-RPE细胞成为治疗黄斑变性的潜在细胞来源。 虽然RPE分化方案已经得到优化，用以提高hiPSC-RPE细胞的疗效，但依然不足，耗时且费力。 为了临床应用，利用对FGF/MAPK信号通路的短暂抑制，利用无饲养层培养条件，开发了一种将“启动”到“naïve”状态的hiPSCs向RPE有效分化的方 …

Our HiPSCs display classic pluripotent stem cell morphology, with a high nucleus to cytoplasm size ratio, as well as they are amenable to be cultivated in serum-free media, independent of feeder cells and of feeder-conditioned media as colonies or high density monolayers. hiPSCs are also evaluated for the presence of karyotypic abnormalities.

hiPSC细胞株来源于ATCC，是将健康男性新生儿包皮细胞诱导成hiPSC，贴壁生长，呈 克隆状，可在hESC/iPSC完全培养基中快速增殖，而边缘分化的细胞则在该培养基中生长