The 4Ts Score is a clinical scoring system to differentiate patients with HIT from those with other causes of thrombocytopenia.

Heparin-induced thrombocytopenia (HIT) is a complication of heparin therapy. HIT is characterized by a 30–50% decrease in platelet count and an increased thrombotic risk due to platelet activation. Without treatment, up to 50% of patients can experience thrombotic events.

Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of exposure to heparin (ie, unfractionated heparin, low molecular weight [LMW] heparin) that occurs in up to 5 percent of patients exposed, regardless of the dose, schedule, or route of administration.

2022年8月12日 · Heparin-induced thrombocytopenia (HIT) is a serious complication of taking the blood thinner heparin. With HIT, your immune system causes your platelets to clot in the presence of heparin, resulting in your platelet levels dropping. Without treatment, the clotting puts you at risk of developing life-threatening blood clots.

In patients with a history of HIT, HIT laboratory testing may be used to define the phase of HIT and an appropriate strategy for intraoperative anticoagulation.

2011年12月10日 · Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-activating IgG antibodies that recognize platelet factor 4 (PF4)/polyanion complexes.

HIT is a severe immune reaction to heparin therapy and is associated with high risk of venous and arterial thrombosis, making diagnosis and management critical for patient care. HIT is suspected when platelet counts decrease within 1 to 10 days after initiation of the treatment.

The SRA is considered the gold standard test for HIT diagnosis because of its high sensitivity and specificity. The test measures the serotonin released from platelets, which correlates with the degree of platelet activation induced by the PF4-heparin antibody complex.

2025年3月5日 · Type II HIT is a much more clinically-significant, immune-mediated response to heparin that is frequently associated with the production of HIPA. Type II HIT can be associated with severe thrombosis, with the platelet count decreasing typically by 50%.

Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin therapy that can cause life-threatening thrombosis. HIT is caused by antibodies directed against heparin-platelet factor 4 (PF4) complexes, which can be detected by enzyme-linked and latex-enhanced immunoassays (IA) that have high diagnostic sensitivity.