Heterogeneous nuclear ribonucleoprotein K (also protein K) is a protein that in humans is encoded by the HNRNPK gene. [5] It is found in the cell nucleus that binds to pre- messenger RNA (mRNA) as a component of heterogeneous ribonucleoprotein particles. The simian homolog is known as protein H16.

Heterogeneous ribonucleoprotein particle （异构核糖核蛋白颗粒）是一类存在于细胞核中的RNA与蛋白复合体，其主要存在在基因转录和随后的新合成的RNA的转录后调控过程中，参与核酸代谢过程。 在RNA合成加工过程中，由于结合在pre-mRNA上的蛋白发出了“pre-mRNA还没有完成加工过程”这样的一个信号，因此未完成加工的pre-mRNA不能运输到细胞质。 在RNA合成加工完成后，成熟的RNA通常会被非常快的从细胞核中运输出去，因此大多数核内的RNA结合蛋白是 …

2024年12月25日 · HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K) is a Protein Coding gene. Diseases associated with HNRNPK include Au-Kline Syndrome and Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To …

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is highly expressed in non-small-cell lung cancer (NSCLC), and NSCLC with higher expression of hnRNP K are more frequently rated as high-grade tumors with poor outcome. hnRNP K increases microtubule stability via interacting with microtubule-associated protein 1B light chain and is associated ...

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a member of the hnRNP family, which exists in the nucleus and the cytoplasm simultaneously. It is a multifunctional protein that can participate in a variety of regulatory progressions of gene ...

2016年5月23日 · Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation.

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an evolutionarily conserved factor encoded by a gene that has been mapped to chromosome 9 in humans [1]. It belongs to the large family of proteins which bind to nascent RNA polymerase II transcripts and are called heterogeneous nuclear RNAs to describe their cellular localization and ...

Since its original identification as a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, K protein has been found not only in the nucleus but also in the cytoplasm and mitochondria and is implicated in chromatin remodeling, transcription, splicing and …

hnRNPs 是 RNA 结合蛋白，它们与异质核 RNA (hnRNA) 复合。 这些蛋白质与细胞核中的前体 mRNA 相关，并且似乎影响前体 mRNA 加工以及 mRNA 代谢和运输的其他方面。 虽然所有的 hnRNP 都存在于细胞核中，但有些似乎在细胞核和细胞质之间穿梭。 hnRNP 蛋白具有独特的核酸结合特性。 该基因编码的蛋白质位于核质中，具有三个与 RNA 结合的 KH 结构域重复序列。 它与其他 hnRNP 蛋白的结合偏好不同；它与 poly (C) 牢固结合。 这种蛋白质也被认为在细胞周期 …

2014年10月1日 · The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as …