The broad-spectrum antiviral functions of IFIT and IFITM proteins
2012年12月14日 · IFN-induced protein with tetratricopeptide repeats (IFIT) proteins — which are induced after type I interferon (IFN)- or IFN-regulatory factor 3 (IRF3)-dependent signalling — …
IFITM3 inhibits virus-triggered induction of type I interferon by ...
2017年4月24日 · In this study, we demonstrate that IFITM3 plays important roles in regulating the RNA-virus-triggered production of IFN-β in a negative-feedback manner. Overexpression of …
IFIT3 mediated the type I interferon antiviral response by …
2022年12月1日 · Gain-of-function screening identified IFIT3 as a potential antiviral effector against SVA infection. IFIT3 targeted SVA entry, assembly and release pathways. IFIT3 was …
Human IFIT3 Protein Induces Interferon Signaling and Inhibits ...
2021年11月2日 · During RNA virus infections, it is known that IFIT3 stimulates IFN production through mitochondrial antiviral signaling (MAVS)-mediated activation of TBK1 which …
How Different Pathologies Are Affected by IFIT Expression
The IFN-stimulated gene factor 3 (ISGF3) complex, consisting of STAT1/2 and IRF-9, binds to an IFN-stimulated response element (ISRE) in the genome and facilitates the transcription of …
IFIT3 在抗病毒先天免疫和细胞生物学中的新作用,Journal of …
2022年10月28日 · IFIT3在基因和蛋白质结构方面具有IFIT家族的典型特征，能够通过经典的PRRs-IFN-JAK/STAT途径被激活。 多种病毒可诱导IFIT3的表达，进而抑制病毒的复制，其潜在机制 …
Overexpression of IFN-induced protein with tetratricopeptide repeats 3 ...
2014年9月17日 · Following viral infection, IFIT induction is conferred directly by activation of IFN-regulatory factor (IRF) 3, which is often activated before the induction of type I IFN [15]. Other …
Roles of interferon induced protein with tetratricopeptide repeats ...
2023年11月1日 · A high level of damaged DNA activates the DNA receptor STING-IRF3 pathway to induce the abnormal expression of IFIT, resulting in immune imbalance, which is more likely …
干扰素诱导蛋白与四肽重复 3（IFIT3）基因 | MCE
干扰素诱导蛋白与四肽重复 3： 实现相同的蛋白质结合活性。 参与细胞凋亡过程的负调控；细胞群增殖的负调节；和对病毒的反应。 位于胞质溶胶和线粒体中。
IFIT3 Gene - GeneCards | IFIT3 Protein | IFIT3 Antibody
2024年12月25日 · IFIT3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) is a Protein Coding gene. Diseases associated with IFIT3 include Lupus Erythematosus and Tuberculosis. …